Synthesis and biological evaluation of novel substituted pyrrolo[2,3-d]pyrimidines as anticancer agents

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dc.contributor.authorDholakia, Sandip P.en_US
dc.contributor.authorKanada, Kaushik B.en_US
dc.contributor.authorParmar, Ghanshyam R.en_US
dc.date.accessioned2020-10-16T08:56:57Z
dc.date.available2020-10-16T08:56:57Z
dc.date.issued2020-06
dc.description.abstractPyrrolopyrimidines are well known scaffold, which play a critical role as anticancer agents, so it thought of interest tosynthesize a series of novel substituted pyrrolo[2,3-d]pyrimidines having diverse groups at position C4 and N7 of thepyrrolo[2,3-d]pyrimidine core and performed in vitro screening against MDA-MB-468 (breast cancer cell line) cellline. The details of the synthetic methods and characterization data of the synthesized compounds have been presentedin this study. Compounds 8a, 8h, 8j, 9h, 9i, 9j, 9m, 9n, and 9o showed the excellent anticancer activity compared tostandard doxorubicin with an IC50 value of 6.17 µM/ml against MDA-MB-468 (breast cancer cell line), which wasnon-toxic to normal vero cell line.en_US
dc.identifier.affiliationsDepartment of Chemistry, Shankersinh Vaghela Bapu Institute of Pharmacy, Gandhinagar, Gujarat, India.en_US
dc.identifier.affiliationsDepartment of Chemistry, Saraswati Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.en_US
dc.identifier.citationDholakia Sandip P., Kanada Kaushik B., Parmar Ghanshyam R.. Synthesis and biological evaluation of novel substituted pyrrolo[2,3-d]pyrimidines as anticancer agents. Journal of Applied Pharmaceutical Science. 2020 Jun; 2020 Jun: 006-011en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210763
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10602en_US
dc.subjectDoxorubicinen_US
dc.subjectpyrrolo[2,3-d] pyrimidineen_US
dc.subjectanticanceren_US
dc.subjectbreast canceren_US
dc.titleSynthesis and biological evaluation of novel substituted pyrrolo[2,3-d]pyrimidines as anticancer agentsen_US
dc.typeJournal Articleen_US
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