Synthesis and biological evaluation of novel substituted pyrrolo[2,3-d]pyrimidines as anticancer agents
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Date
2020-06
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
Pyrrolopyrimidines are well known scaffold, which play a critical role as anticancer agents, so it thought of interest tosynthesize a series of novel substituted pyrrolo[2,3-d]pyrimidines having diverse groups at position C4 and N7 of thepyrrolo[2,3-d]pyrimidine core and performed in vitro screening against MDA-MB-468 (breast cancer cell line) cellline. The details of the synthetic methods and characterization data of the synthesized compounds have been presentedin this study. Compounds 8a, 8h, 8j, 9h, 9i, 9j, 9m, 9n, and 9o showed the excellent anticancer activity compared tostandard doxorubicin with an IC50 value of 6.17 µM/ml against MDA-MB-468 (breast cancer cell line), which wasnon-toxic to normal vero cell line.
Description
Keywords
Doxorubicin, pyrrolo[2,3-d] pyrimidine, anticancer, breast cancer
Citation
Dholakia Sandip P., Kanada Kaushik B., Parmar Ghanshyam R.. Synthesis and biological evaluation of novel substituted pyrrolo[2,3-d]pyrimidines as anticancer agents. Journal of Applied Pharmaceutical Science. 2020 Jun; 2020 Jun: 006-011