Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report
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Date
2025-03
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer - Medknow
Abstract
Primary non?Hodgkin bone lymphoma is a rare disease, and within this category, B?cell lymphoblastic lymphoma (B?LBL) is an even rare clinical entity that has only been reported in small case series or individual case reports. B?LBL can mimic Ewing’s sarcoma both clinically and histologically, leading to misdiagnosis. We present a case of primary B?LBL of the bone in a 7?year?old girl. The tumor cells are uniform and small with a diffuse and infiltrative growth pattern similar to EWS. Immunohistochemical results are positive for CD99, Fli?1, ERG, TDT, PAX5, and CD79?, but negative for leukocyte common antigen, CD3, CD20, and NKX2.2. No other lesions are found on positron emission tomography/ computed tomography imaging. Finally, primary solitary bone B?LBL of the right tibia was diagnosed.
Description
Keywords
B?cells lymphoblastic lymphoma, Ewing’s sarcoma, ERG, Fli?1, primary bone lymphoma
Citation
Chen H, Li JS, Huang Y. Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 219-221