Sustained-release niacin induced acute liver failure: an autopsy report

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dc.contributor.authorTariq, Hamzaen_US
dc.contributor.authorSharkey, Francis E.en_US
dc.date.accessioned2020-04-23T07:48:49Z
dc.date.available2020-04-23T07:48:49Z
dc.date.issued2018-03
dc.description.abstractNiacin, either alone or in combination with other anti-hyperlipidemic agents, safely and effectively addresses most lipid abnormalities in patients with mixed dyslipidemias. Niacin is the only available agent that significantly lowers lipoprotein (a) and has the greatest high density lipoprotein cholesterol-raising effects of all available agents. Despite niacin’s numerous beneficial lipid effects, patient compliance to long-term therapy is challenged by its common side effects which include nausea, pruritus, and vasodilatory flushing. The incidence of these unpleasant side effects in patients taking the Immediate Release (IR) form of the drug is close to 100 %. To avoid these side effects, Sustained Release (SR) formulations of the drug were created which lower the rate of nausea, flushing and pruritus markedly. Unfortunately, the SR form is associated with a high incidence of chemical hepatitis and rarely fulminant hepatic failure, which is not seen in patients taking the IR form. We report the autopsy findings of a 68 years old man who died of fulminant liver failure three weeks after switching from IR to SR form of niacin. All other toxic, infectious and autoimmune causes of liver failure were ruled out clinically. His liver biopsy one-week antemortem was consistent with chemical hepatitis, such as has been described for slow-release niacin. At autopsy the liver showed diffuse massive hepatic necrosis with no background fibrosis. SR Niacin is widely available over the counter; however, there is substantial scientific evidence that the drug is associated with potentially fatal hepatotoxicity.en_US
dc.identifier.affiliationsDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, Texas, USA, 78229en_US
dc.identifier.citationTariq Hamza, Sharkey Francis E.. Sustained-release niacin induced acute liver failure: an autopsy report. International Journal of Basic & Clinical Pharmacology. 2018 Mar; 7(3): 569-572en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199613
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20180675en_US
dc.subjectNiacinen_US
dc.subjectFlushingen_US
dc.subjectHepatotoxicityen_US
dc.subjectSustained releaseen_US
dc.titleSustained-release niacin induced acute liver failure: an autopsy reporten_US
dc.typeJournal Articleen_US
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