A novel search engine for proteins involved in Notch crosstalk signaling pathways

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dc.contributor.authorSANJEEVI, MADHUMATHIen_US
dc.contributor.authorRAJENDRAN, SANTHOSHen_US
dc.contributor.authorRAMACHANDRAN, DHANALAKSHMIen_US
dc.contributor.authorRAHUL, CHANDRASEKAR NARAYANANen_US
dc.contributor.authorJEYARAMAN, JEYAKANTHANen_US
dc.contributor.authorKANAGARAJ, SEKARen_US
dc.date.accessioned2024-11-30T11:24:39Z
dc.date.available2024-11-30T11:24:39Z
dc.date.issued2023-12
dc.description.abstractTo regulate biological activity in humans, the Notch signaling pathway (NSP) plays an essential role in a wide array of cellular development and differentiation process. In recent years, many studies have reported that aberrant activation of Notch is associated with the tumor process; but no appropriate database exists to fill this significant gap. To address this, we created a pioneering database NCSp, which is open access and comprises intercommunicating pathways and related protein mutations. This allows scientists to understand better the cause of single amino acid mutations in proteins. Therefore, NCSp provides information on the predicted functional effect of human protein mutations, which aids in understanding the importance of mutations linked to the Notch crosstalk signaling pathways in cancerous and non-cancerous systems. This database might be helpful for therapeutic mutation analysis, molecular biology, and structural biology researchers. The NCSp database can be accessed through https://bioserver3.physics.iisc.ac.in/cgi-bin/nccspd/.en_US
dc.identifier.affiliationsStructural Biology and Bio Computing Laboratory, Department of Bioinformatics, Alagappa University, Karaikudi 630004, Indiaen_US
dc.identifier.affiliationsDepartment of Computational and Data Sciences, Indian Institute of Science, Bengaluru 560012, Indiaen_US
dc.identifier.affiliationsStructural Biology and Bio Computing Laboratory, Department of Bioinformatics, Alagappa University, Karaikudi 630004, Indiaen_US
dc.identifier.affiliationsStructural Biology and Bio Computing Laboratory, Department of Bioinformatics, Alagappa University, Karaikudi 630004, Indiaen_US
dc.identifier.affiliationsDepartment of Computational and Data Sciences, Indian Institute of Science, Bengaluru 560012, Indiaen_US
dc.identifier.citationSANJEEVI MADHUMATHI, RAJENDRAN SANTHOSH, RAMACHANDRAN DHANALAKSHMI, RAHUL CHANDRASEKAR NARAYANAN, JEYARAMAN JEYAKANTHAN, KANAGARAJ SEKAR. A novel search engine for proteins involved in Notch crosstalk signaling pathways. Journal of Biosciences. 2023 Dec; 49: 1-13en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237933
dc.languageenen_US
dc.publisherThe Indian Academy of Sciencesen_US
dc.relation.volume49en_US
dc.source.urihttps://doi.org/10.1007/s12038-023-00395-7en_US
dc.subjectCanceren_US
dc.subjectcrosstalk pathwayen_US
dc.subjectdatabaseen_US
dc.subjectmutations effecten_US
dc.subjectNotch signallingen_US
dc.subjectpathwaysen_US
dc.subjectproteinsen_US
dc.titleA novel search engine for proteins involved in Notch crosstalk signaling pathwaysen_US
dc.typeJournal Articleen_US
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