A novel search engine for proteins involved in Notch crosstalk signaling pathways
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Date
2023-12
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Volume Title
Publisher
The Indian Academy of Sciences
Abstract
To regulate biological activity in humans, the Notch signaling pathway (NSP) plays an essential role in a wide array of cellular development and differentiation process. In recent years, many studies have reported that aberrant activation of Notch is associated with the tumor process; but no appropriate database exists to fill this significant gap. To address this, we created a pioneering database NCSp, which is open access and comprises intercommunicating pathways and related protein mutations. This allows scientists to understand better the cause of single amino acid mutations in proteins. Therefore, NCSp provides information on the predicted functional effect of human protein mutations, which aids in understanding the importance of mutations linked to the Notch crosstalk signaling pathways in cancerous and non-cancerous systems. This database might be helpful for therapeutic mutation analysis, molecular biology, and structural biology researchers. The NCSp database can be accessed through https://bioserver3.physics.iisc.ac.in/cgi-bin/nccspd/.
Description
Keywords
Cancer, crosstalk pathway, database, mutations effect, Notch signalling, pathways, proteins
Citation
SANJEEVI MADHUMATHI, RAJENDRAN SANTHOSH, RAMACHANDRAN DHANALAKSHMI, RAHUL CHANDRASEKAR NARAYANAN, JEYARAMAN JEYAKANTHAN, KANAGARAJ SEKAR. A novel search engine for proteins involved in Notch crosstalk signaling pathways. Journal of Biosciences. 2023 Dec; 49: 1-13