1,2,3-TRIAZOLE CARBOXAMIDE DERIVATIVES AS NOVEL PROSPECTIVE ANTICANCER AGENTS: SYNTHESIS, CHARACTERIZATION AND IN-SILICO STUDIES

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dc.contributor.authorSharma, Dipesh Kumaren_US
dc.contributor.authorSingh, Surabhien_US
dc.date.accessioned2024-09-24T08:59:13Z
dc.date.accessioned2024-09-24T11:51:29Z
dc.date.available2024-09-24T08:59:13Z
dc.date.available2024-09-24T11:51:29Z
dc.date.issued2024-04
dc.description.abstractThe ongoing and persistent endeavour to discover effective new anticancer medications remains a steadfast objective. Presently, the focus of this research lies in exploring novel substituted derivatives of 1,2,3-triazole carboxamide. A set of novel derivatives of 1,2,3-triazole carboxamide(5a-5n) were successfully synthesized with yields ranging from satisfactory to excellent. These compounds underwent characterization using various analytical methods, such as 1H NMR, 13C NMR, and mass spectrometry. Their cytotoxic potential against four cancer cell lines—HeLa, PANC-1, HCT-116, and A-549—was evaluated in vitro. Notably, compounds 5j, 5i, 5m, and 5f displayed significant anticancer activity. Molecular docking experiments were conducted on the synthesized compounds, revealing strong binding interactions with the active sites of EGFR and CDK4-Cyclin D3. However, out of all the derivatives tested, namely 5i, 5j, 5g, 5f, and 5h, it was observed that these compounds displayed a favourable binding affinity towards both the EGFR and the CDK4-Cyclin D3 active site. The results of the study suggest that the synthesised compounds have potential as agents for cancer therapy. Furthermore, further alterations to the structure of triazole-carboxamide derivatives could lead to the development of effective anticancer drugs.en_US
dc.identifier.affiliationsSchool of Basic and Applied Sciences, Career Point University, Kota, Rajasthan Indiaen_US
dc.identifier.affiliationsSchool of Basic and Applied Sciences, Career Point University, Kota, Rajasthan Indiaen_US
dc.identifier.citationSharma Dipesh Kumar, Singh Surabhi . 1,2,3-TRIAZOLE CARBOXAMIDE DERIVATIVES AS NOVEL PROSPECTIVE ANTICANCER AGENTS: SYNTHESIS, CHARACTERIZATION AND IN-SILICO STUDIES . International Journal of Pharmaceutical Sciences and Drug Research . 2024 Mar; 16(2): 213-219en_US
dc.identifier.issn0975–248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231615
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2024.160211en_US
dc.subject1,2,3-triazoleen_US
dc.subjectAnticanceren_US
dc.subjectMTT assayen_US
dc.subjectEGFRen_US
dc.subjectCDK-4en_US
dc.title1,2,3-TRIAZOLE CARBOXAMIDE DERIVATIVES AS NOVEL PROSPECTIVE ANTICANCER AGENTS: SYNTHESIS, CHARACTERIZATION AND IN-SILICO STUDIESen_US
dc.typeJournal Articleen_US
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