Phytochemical and Pharmacological Screening for Antidiabetic Activity of Salvia aegyptiaca L. Ethanolic Leaves Extract

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dc.contributor.authorAhmad, Fazilen_US
dc.contributor.authorAl-Subaie, Abeer Mohammeden_US
dc.contributor.authorShaik, Rasheed Ahemaden_US
dc.contributor.authorMohamed, J. Muthuen_US
dc.contributor.authorMohammad, Abdul Saleemen_US
dc.date.accessioned2020-11-18T10:30:13Z
dc.date.available2020-11-18T10:30:13Z
dc.date.issued2020-07
dc.description.abstractDiabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein, which results in high levels of glucose in the body after a meal or fasting. This disease is caused by the absence or reduction of insulin secretion. Accordingly, diabetes is usually classified into two types, Type 1(IDDM) and Type II (NIDDM). The aim of the present study is to carry the phytochemical analysis and antidiabetic activity of Salvia aegyptiaca Lethanolic leaves extract. Phytochemical study was carried out by standard methods, shows the presence of various phytochemical constituents such as, phenols, flavonoids, steroids, proteins, glycosides, carbohydrates, lipids, alkaloids, tannins and terpenoids, while saponins shown to be absent. Antidiabetic activity of Salvia aegyptiaca Lwere carried out in both normoglycemic and diabetic induced rats. Normoglycemic animal group were fed with ethanolic leaves extract of Salvia aegyptiaca Lat a dose of 250mg/kg and 500mg/kg alone for 14days, showed decrease in blood glucose level. In diabetic animal group the rats were made diabetic by intraperitoneal(i.p) injection of 100 mg/kg alloxan monohydrate, then followed by administration of ethanolic leaves extract of Salvia aegyptiaca(250mg/kg and 500mg/kg) and standard Tolbutamide (50mg/kg,p.o) for14 days. The results of the diabetic induced group also showed decrease in glucose levels. The results of thecurrent investigation demonstrate that various phytochemical present in Salvia aegyptiaca Lethanolic leaves extracts, might be responsible for antidiabetic effect, due to its known antioxidant propertyen_US
dc.identifier.affiliationsDepartment of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, P.O.Box 4030, Jubail, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, P.O.Box 1982, Dammam, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Pharmacology andToxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Technology, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Hyderabad -500004, Telangana, Indiaen_US
dc.identifier.citationAhmad Fazil, Al-Subaie Abeer Mohammed, Shaik Rasheed Ahemad, Mohamed J. Muthu, Mohammad Abdul Saleem. Phytochemical and Pharmacological Screening for Antidiabetic Activity of Salvia aegyptiaca L. Ethanolic Leaves Extract. Journal of Pharmaceutical Research International. 2020 Jul; 32(12): 122-131en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215810
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber12en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i1230569en_US
dc.subjectSalvia aegyptiaca Len_US
dc.subjectethanolen_US
dc.subjectinsulinen_US
dc.subjectantioxidanten_US
dc.subjecttolbutamideen_US
dc.subjectdiabetes mellitusen_US
dc.titlePhytochemical and Pharmacological Screening for Antidiabetic Activity of Salvia aegyptiaca L. Ethanolic Leaves Extracten_US
dc.typeJournal Articleen_US
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