Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease.

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dc.contributor.authorOlazarán, Javier
dc.contributor.authorGarcía-Polo, Pablo
dc.contributor.authorGarcía-Frank, Daniel
dc.contributor.authorQuirós, Alicia
dc.contributor.authorHernández-Tamames, Juan Antonio
dc.contributor.authorAcedo, Carmen
dc.contributor.authorÁlvarez-Linera, Juan
dc.contributor.authorFrank, Ana
dc.date.accessioned2017-02-01T09:02:37Z
dc.date.available2017-02-01T09:02:37Z
dc.date.issued2016
dc.description.abstractBackground/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD). Methods: Subjects aged 65 or more were categorized as prodromal AD (n=18), mild AD (n=35), or normal cognition (n=76). Depressive symptoms were measured by means of the 15-item abridged version of the Geriatric Depression Scale. Potential gray matter correlates of depressive symptoms were analyzed using the Statistical Parametric Mapping software package. Results: Significant results were obtained in the prodromal AD group only. In that group, depressive symptoms were related to atrophy in the left precentral gyrus (Brodmann area 6) (p≤0.01, FWE corrected). Conclusion: Our results, added to the existing literature, suggest that dysfunction in left-sided, cognitively and functionally salient, cortical regions along with relative preservation of deficit awareness, provided by the right hemisphere, explain depressive symptoms in the initial clinical stages of AD.en_US
dc.identifier.citationOlazarán Javier, García-Polo Pablo, García-Frank Daniel, Quirós Alicia, Hernández-Tamames Juan Antonio, Acedo Carmen, Álvarez-Linera Juan, Frank Ana. Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease. British Journal of Medicine and Medical Research. 2016; 14(4): 1-10.en_US
dc.identifier.issn2231-0614
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/182782
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/abstract/13594en_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectdepressionen_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectstructural correlatesen_US
dc.titleStructural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease.en_US
dc.typeArticleen_US
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