Cytokine gene polymorphism (interleukin-1β +3954, Interleukin-6 [−597/−174] and tumor necrosis factor-α −308) in chronic periodontitis with and without type 2 diabetes mellitus.

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dc.contributor.authorSharma, Nitin
dc.contributor.authorJoseph, Rosamma
dc.contributor.authorArun, R
dc.contributor.authorChandni, R
dc.contributor.authorSrinivas, K Lekshmy
dc.contributor.authorBanerjee, Moinak
dc.date.accessioned2015-01-05T04:56:21Z
dc.date.available2015-01-05T04:56:21Z
dc.date.issued2014-05
dc.description.abstractBackground: Pro-inflammatory cytokine gene polymorphisms are potential candidates for susceptibility for both type 2 diabetes mellitus (DM) and chronic periodontitis (CHP). This study explored the association of interleukin‑1 beta (IL‑1 β) +3954, interleukin‑6 (IL‑6) −597/−174 and tumor necrosis factor‑alpha (TNF‑α) −308 single nucleotide polymorphisms in CHP with and without type 2 DM in Malayalam speaking subjects of Dravidian ethnicity. Materials and Methods: This case control study consisted of 51 chronic periodontitis with type 2 diabetes mellitus (CHPDM) and 51 CHP patients as cases and 51 healthy subjects as controls. Polymorphisms were identified by polymerase chain reaction amplification followed by restriction enzyme digestion and gel electrophoresis. Results: IL‑1 β (+3954) TT genotype and T allele were significantly associated with CHPDM group when compared with CHP (P = 0.001), whereas CC genotype and allele C was higher in CHP subjects (P = 0.001). For IL‑6 (−597) frequency of genotype GA/AA (P = 0.04) and allele A (P = 0.01) was lower in CHPDM group, and for TNF‑α −308 the frequency of genotype GA (P = 0.01) and allele A (P = 0.01) was higher in CHP subjects when compared with controls. Conclusions: In Malayalam speaking Dravidian population, IL‑6 (−597) genotype GA/AA and allele A appears to be protective for CHP with type 2 DM. Allele C of IL‑1 β +3954 and allele A of TNF‑α −308 appears to be risk factors for CHP individuals.en_US
dc.identifier.citationSharma Nitin, Joseph Rosamma, Arun R, Chandni R, Srinivas K Lekshmy, Banerjee Moinak. Cytokine gene polymorphism (interleukin-1β +3954, Interleukin-6 [−597/−174] and tumor necrosis factor-α −308) in chronic periodontitis with and without type 2 diabetes mellitus. Indian Journal of Dental Research. 2014 May-Jun; 25(3): 375-380.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154594
dc.language.isoenen_US
dc.source.urihttps://www.ijdr.in/article.asp?issn=0970-9290;year=2014;volume=25;issue=3;spage=375;epage=380;aulast=Sharmaen_US
dc.subjectCytokinesen_US
dc.subjectperiodontitisen_US
dc.subjectpolymorphismen_US
dc.subjectsingle nucleotideen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.subject.meshCytokines --genetics
dc.subject.meshDiabetes Mellitus, Type 2 --genetics
dc.subject.meshInterleukin-6 --genetics
dc.subject.meshPeriodontitis --genetics
dc.subject.meshPolymorphism, Genetics --genetics
dc.subject.meshPolymorphism, Single Nucleotide --genetics
dc.titleCytokine gene polymorphism (interleukin-1β +3954, Interleukin-6 [−597/−174] and tumor necrosis factor-α −308) in chronic periodontitis with and without type 2 diabetes mellitus.en_US
dc.typeArticleen_US
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