Optimization of Extraction Conditions of Polyphenols and Flavonoids from Olax subscorpioidea leaves, a Medicinal Plant Traditionally Used in Korhogo (Cote d’ivoire)

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dc.contributor.authorFrançois, KYKen_US
dc.contributor.authorYves, KYen_US
dc.contributor.authorAka, MBen_US
dc.contributor.authorIsabelle, YYen_US
dc.contributor.authorAbdoulaye, Ten_US
dc.contributor.authorFélix, YH.en_US
dc.date.accessioned2024-12-07T11:20:20Z
dc.date.available2024-12-07T11:20:20Z
dc.date.issued2024-11
dc.description.abstractSecondary metabolites, including polyphenols and flavonoids, play a key role in the expression of the active principles of several medicinal plants from Côte d'Ivoire, such as Olax subscorpioidea Oliv. This study was initiated to help improve conditions for extracting polyphenols and flavonoids from Olax subscorpioidea Oliv leaves harvested in Korhogo. Experimental design methodology was used. The effect of four independent variables on polyphenol and flavonoid content was evaluated: extraction time (12h-24h), evaporation temperature (45°C - 55°C), plant material-solvent ratio (1/20 g/mL - 1/5 g/mL) and ethanol proportion (20% - 100%). The Central Composite Design (CCD) was used to optimize responses after factor screening using the Plackett and Burman design. Optimum extraction conditions were obtained with an ethanolic proportion of 88.29% and 17g of Olax subscorpioidea Oliv leaves dissolved in 100 mL ethanol. The experimental values (96.31 ± 5.29 mg Eq AG/g for polyphenols and 62.44 ± 4.58 mg Eq Q/g) were close to those expected (94.51 mg Eq AG/g for polyphenols and 58.22 mg Eq Q/g for flavonoids), confirming the relevance of the mathematical model used and the success of the response surface methodology in optimizing the extraction conditions of the system studied. These results show that by taking extraction conditions into account in this preliminary study, we can optimize the quantities of secondary metabolites of therapeutic interest.en_US
dc.identifier.affiliationsDepartment of Biochemistry-Genetics, Training and Research Unit of Biological Sciences, Peleforo Gon Coulibaly University, Korhogo, BP 1328, Cote d’Ivoireen_US
dc.identifier.affiliationsDepartment of Biochemistry-Genetics, Training and Research Unit of Biological Sciences, Peleforo Gon Coulibaly University, Korhogo, BP 1328, Cote d’Ivoireen_US
dc.identifier.affiliationsDepartment of Biochemistry-Genetics, Training and Research Unit of Biological Sciences, Peleforo Gon Coulibaly University, Korhogo, BP 1328, Cote d’Ivoireen_US
dc.identifier.affiliationsDepartment of Biochemistry-Genetics, Training and Research Unit of Biological Sciences, Peleforo Gon Coulibaly University, Korhogo, BP 1328, Cote d’Ivoireen_US
dc.identifier.affiliationsDepartment of Biochemistry-Genetics, Training and Research Unit of Biological Sciences, Peleforo Gon Coulibaly University, Korhogo, BP 1328, Cote d’Ivoireen_US
dc.identifier.affiliationsLaboratory of Pharmacodynamics Biochemistry, UFR Biosciences, Félix Houphouët-Boigny University, BP, 582, Abidjan 22- Côte d’Ivoire.en_US
dc.identifier.citationFrançois KYK, Yves KY, Aka MB, Isabelle YY, Abdoulaye T, Félix YH.. Optimization of Extraction Conditions of Polyphenols and Flavonoids from Olax subscorpioidea leaves, a Medicinal Plant Traditionally Used in Korhogo (Cote d’ivoire) . European Journal of Medicinal Plants. 2024 Nov; 35(6): 281-289en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/241350
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber6en_US
dc.relation.volume35en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2024/v35i61226en_US
dc.subjectPolyphenolsen_US
dc.subjectflavonoidsen_US
dc.subjectOlax subscorpioideaen_US
dc.subjectCCDen_US
dc.titleOptimization of Extraction Conditions of Polyphenols and Flavonoids from Olax subscorpioidea leaves, a Medicinal Plant Traditionally Used in Korhogo (Cote d’ivoire)en_US
dc.typeJournal Articleen_US
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