Effect of Cucumber (Cucumis sativus) Fruit Homogenate on Hypotonicity� induced Haemolysis of Red Blood Cell

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dc.contributor.authorAgatemor, Uzuazokaro Mark-Mariaen_US
dc.contributor.authorNwodo, Okwesili Fred Chiligueen_US
dc.date.accessioned2024-09-24T06:22:58Z
dc.date.available2024-09-24T06:22:58Z
dc.date.issued2024-06
dc.description.abstractBackground: Several findings and reports show that people with high intake of Cucumis sativus (Cucumber) have relief in pains, swelling and other inflammatory signs. Human red blood cell membrane stabilization has been used as a method to investigate the mechanism of action of anti-inflammatory drugs. The anti-inflammatory activity of cucumber has been demonstrated in previous study. In this study, we aimed at assessing the effect of cucumber (Cucumis sativus) fruit homogenate on hypotonicity � induced haemolysis of red blood cell.Methods: Whole fresh blood (3 ml) was collected from healthy volunteer into plastic tubes containing 0.1 volume of 3.8% trisodium citrate and used within 8 hr. The blood sample was centrifuged at 3000 x g for 10 min and the supernatant (plasma) discarded. The pellet was washed twice by resuspending in a volume of normal saline equal to the volume of the supernatant (plasma) and centrifuged at 3000 x g for 10 min. The pellet (0.1 ml) was resuspended in 2.5 ml of normal saline and used as the red blood cell (RBC).Results: The results revealed that cucumber (Cucumis sativus) fruit homogenate significantly (p ? 0.05) inhibited hypotonicity-induced red blood cell haemolysis when compared to indomethacin (a known standard drug).Conclusion: Cucumber has membrane stabilization effect on the red blood cell.en_US
dc.identifier.affiliationsResearch and Development, First Focus Research, Nottingham, United Kingdomen_US
dc.identifier.affiliationsResearch and Development, First Focus Research, Nottingham, United Kingdomen_US
dc.identifier.citationAgatemor Uzuazokaro Mark-Maria, Nwodo Okwesili Fred Chiligue. Effect of Cucumber (Cucumis sativus) Fruit Homogenate on Hypotonicity� induced Haemolysis of Red Blood Cell . International Journal of Medical Research & Health Sciences. 2024-Jun; 33(6): 11-16en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226847
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber6en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/10.9734/ijbcrr/2024/v33i6884en_US
dc.subjectHypotonicityen_US
dc.subjectDepartmentmembrane stabilizationen_US
dc.subjectDepartmentred blood cellsen_US
dc.subjectDepartmentinflammationen_US
dc.subjectDepartmenthomogenateen_US
dc.subjectDepartmentCucumis sativusen_US
dc.titleEffect of Cucumber (Cucumis sativus) Fruit Homogenate on Hypotonicity� induced Haemolysis of Red Blood Cellen_US
dc.typeJournal Articleen_US
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