Antioxidant potential and oxidative DNA damage preventive activity of unexplored endemic species of Curcuma.

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dc.contributor.authorRajan, Iyyappan
dc.contributor.authorRabindran, Remitha
dc.contributor.authorJayasree, P R
dc.contributor.authorKumar, P R M
dc.date.accessioned2014-04-29T11:06:14Z
dc.date.available2014-04-29T11:06:14Z
dc.date.issued2014-02
dc.description.abstractFree radical scavenging activity, ferrous ion chelating capacity, reducing power and genoprotective effect of the aqueous leaf extracts of four unexplored endemic Curcuma spp. (C. vamana, C. neilgherrensis, C. mutabilis, C. haritha) were found to be dose-dependent and were highest in C. vamana. DNA protection property of the extracts was evaluated against H2O2/UV-induced oxidative damage. DNA-methyl green displacement assay showed that these extracts were free of DNA intercalating compounds. Further, hemolysis assay also showed that the extracts were non-toxic to human erythrocytes. The results highlight C. vamana as a promising source for herbal preparations possessing high antioxidant potential and genoprotective activity.en_US
dc.identifier.citationRajan Iyyappan, Rabindran Remitha, Jayasree P R, Kumar P R M. Antioxidant potential and oxidative DNA damage preventive activity of unexplored endemic species of Curcuma. Indian Journal of Experimental Biology. 2014 Feb; 52(2): 133-138.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150341
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/26435en_US
dc.subjectAntioxidanten_US
dc.subjectGenoprotectionen_US
dc.subjectIron chelationen_US
dc.subject.meshAntioxidants --pharmacology
dc.subject.meshCurcuma --chemistry
dc.subject.meshDNA Damage --drug effects
dc.subject.meshDNA, Plant --drug effects
dc.subject.meshFree Radical Scavengers --metabolism
dc.subject.meshFree Radical Scavengers --pharmacology
dc.subject.meshHumans
dc.subject.meshIron Chelating Agents --metabolism
dc.subject.meshIron Chelating Agents --pharmacology
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshPhysarum polycephalum --drug effects
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Leaves --chemistry
dc.titleAntioxidant potential and oxidative DNA damage preventive activity of unexplored endemic species of Curcuma.en_US
dc.typeArticleen_US
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