Preparation and Evaluation of Solid Dispersions of Ibuprofen Using Glucosamine HCl as a Carrier.
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Date
2013-10
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Abstract
Aims: The aim of this study was to enhance the solubility and dissolution rate of sparingly
soluble drug ibuprofen using glucosamine HCL as a carrier by solid dispersion technique.
Methodology: As Ibuprofen is sparingly water-soluble drug and has low bioavailability, so
to enhance its solubility and improve bioavailability solid dispersions with different drug to
carrier ratios (1:1, 1:2 and 1:3) were prepared, as solid dispersion is the most effective
method for enhancing the solubility and improving the bioavailability of poorly or sparingly
water- soluble drugs. In this study Glucosamine HCl was used as a potential hydrophilic
carrier to improve the solubility, dissolution rate and bioavailability of poorly water-soluble
drug, Ibuprofen from physical mixtures and solid dispersions. Solid dispersions with
different drug to carrier ratios were prepared, using solvent evaporation method. Physical
mixtures of Ibuprofen and Glucosamine HCl were also prepared for comparison.
Results: All solid dispersions of Ibuprofen and Glucosamine showed considerably higher dissolution rate than corresponding physical mixtures and pure Ibuprofen. Different
techniques such DSC, FT-IR, XRD and SEM were used to study the properties of pure
Ibuprofen, solid dispersions and physical mixtures. These results confirmed that
Glucosamine HCl can increase the solubility and dissolution rate of poorly water-soluble
drug, Ibuprofen.
Conclusion: The study shows that the dissolution rate and solubility of sparingly soluble
drug Ibuprofen can be improved and enhanced to great extent by solid dispersion
technique, using Glucosamine HCl as a carreir. The current study also showed that amino
sugar could be used as new carrier for solid dispersion formulations of non-steroidal antiinflammatory
drugs.
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Keywords
Solid dispersions, ibuprofen, glucosamine hcl, solvent evaporation, solubility, dissolution rate
Citation
Wahab Abdul, Khan Amjad, Khan Gul Majid. Preparation and Evaluation of Solid Dispersions of Ibuprofen Using Glucosamine HCl as a Carrier. British Journal of Pharmaceutical Research. 2013 Oct; 3(4): 722-733.