Role of Histone Deacetylases (HDAC) and Histone Deacetylases Inhibitors (HDACis) in Oral Cancer: A Literature Review with Concept-Centric Approach applying Synthesis Matrix Framework (SMF).
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Date
2025-06
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Publisher
Kairali Society of Oral & Maxillofacial Pathologists
Abstract
Introduction: Based on the Synthesis Matrix Framework, this narrative review with concept-centric approach was conceptualized with the aim to pen down the existing knowledge regarding Histone Deacetylases and Histone Deacetylases inhibitors in oral cancer by synthesizing few evidence-based research studies applying time-ordered matrix framework and role-ordered matrix framework design. Material and Methods: Google scholar and PubMed search engine were implemented with search strings using Boolean keywords such as “oral squamous cell carcinoma”, “OSCC”, “oral cancer”, “etiological factors of Oral Cancer”, “diagnosis of Oral Cancer”, “HDAC in Oral cancer”, HDACis in Oral cancer”, “HDAC in OSCC”, “HDACis in OSCC”. The review was further assessed by using a three category rubrics of literature review (coverage, synthesis and significance) uncovering the normal function of Histone Deacetylases, classification, molecular mechanism, future directions in research with challenges that can be encountered before the Histone Deacetylases inhibitors are applied in clinical practice. Conclusion: This review highlights a brief overview on importance of applying Synthesis Matrix Framework as a guiding principle in the field of scientific writing and hence should be included as a modification in curriculum design by educationalist and policy reformers in higher education as quality enhancement initiative in the discipline of research.
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Keywords
Histone Deacetylases, Histone Deacetylases Inhibitors, Literature Review, Oral Cancer, Synthesis Matrix Framework
Citation
Bommanavar S, Hosmani J, Alqarni A, AlHousami T, Zaki H.. Role of Histone Deacetylases (HDAC) and Histone Deacetylases Inhibitors (HDACis) in Oral Cancer: A Literature Review with Concept-Centric Approach applying Synthesis Matrix Framework (SMF).. Oral and Maxillofacial Pathology Journal. 2025 Jun; 16(1): 50-56