Possible role of glutathione in resistance to heavy metals and hydrogen peroxide in a radioresistant Chinese hamster V79 cell strain.

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dc.contributor.authorSengupta, Sen_US
dc.contributor.authorBhattacharyya, N Pen_US
dc.date.accessioned2009-05-28T11:38:14Z
dc.date.available2009-05-28T11:38:14Z
dc.date.issued1996-09-01en_US
dc.description.abstractTo understand the cellular and biochemical nature of radioresistance in the strain M5 derived from Chinese hamster V79 cells, the sensitivity of the resistant cells towards CdCl2, Zn(Ac)2, and H2O2 by the colony forming ability has been tested. D0 values for these compounds in Chinese hamster V79 cells were 5.4 microM, 27.8 microM and 4.3 micrograms/ml respectively while for M5 cells these were 8.3 microM, 142.9 microM and 11.9 micrograms/ml respectively. The resistance to heavy metals as well as the oxidative damage could be reversed by the inhibition of glutathione synthesis by the drug buthionine sulfoximine (BSO). These set of data indicate that the cellular antioxidant glutathione plays an important role in the observed oxidant-resistant phenotype as well as heavy metal resistance in M5 cells.en_US
dc.description.affiliationSaha Institute of Nuclear Physics, Crystallography and Molecular Biology Division, Bidhan Nagar, Calcutta, India.en_US
dc.identifier.citationSengupta S, Bhattacharyya NP. Possible role of glutathione in resistance to heavy metals and hydrogen peroxide in a radioresistant Chinese hamster V79 cell strain. Indian Journal of Experimental Biology. 1996 Sep; 34(9): 905-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56990
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshButhionine Sulfoximine --pharmacologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshCricetulusen_US
dc.subject.meshGlutathione --antagonists & inhibitorsen_US
dc.subject.meshHydrogen Peroxide --toxicityen_US
dc.subject.meshMaleen_US
dc.subject.meshMetals --toxicityen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRadiation Toleranceen_US
dc.titlePossible role of glutathione in resistance to heavy metals and hydrogen peroxide in a radioresistant Chinese hamster V79 cell strain.en_US
dc.typeJournal Articleen_US
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