Effects of steroid hormones on total brain Na(+)-k+ ATPase activity in Oreochromis mossambicus.

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dc.contributor.authorSunny, Francisen_US
dc.contributor.authorOommen, V Oommenen_US
dc.date.accessioned2009-05-28T12:02:11Z
dc.date.available2009-05-28T12:02:11Z
dc.date.issued2004-03-06en_US
dc.description.abstractThe effects of administration of cortisol, corticosterone, testosterone, progesterone and a synthetic estrogen. diethylstilbestrol (DES) on total brain Na(+)-K+- ATPase were investigated in tilapia, O. mossambicus. Exogenous administration of 0.125 and 0.25 microg/g body weight of glucocorticoids and 0.125, 0.25 and 0.5 microg/g body weight of DES for 5 days significantly stimulated Na+(-) K+ ATPase activity by 14-41% in the brain, while 0.5 microg/g body weight of glucocorticoids did not evoke any response on the activity of the enzyme. Progesterone (0.125 and 0.25 microg/g body weight) administration significantly decreased the enzyme activity by 21-36% and high dose (0.5 microg/g body weight) was ineffective. Testosterone exhibited a biphasic effect on Na(+)-K+ ATPase activity--a low dose stimulated by 14% while middle and high doses inhibited it by 19-24%. The results seem to be the first report on the effect of steroids on brain ATPase activity in a teleost. When 0.25microg/g body weight of actinomycin D or puromycin was administered prior to the treatment of similar doses of hormones, the inhibitors significantly inhibited the effect of the hormones by 24-52%. This clearly shows that the effect of the hormones was sensitive to the action of inhibitors suggesting a possible genomic mode of action under long-term treatment. The results suggest that cortisol, corticosterone and DES may possibly stimulate the co-transport of glucose and excitation of membrane potential while progesterone and testosterone inhibit them in the brain of O. mossambicus by regulating the activity of Na(+)-K+ ATPase.en_US
dc.description.affiliationDepartment of Zoology, University College, Trivandrum 695 034, India. fsnature@sancharnet.inen_US
dc.identifier.citationSunny F, Oommen VO. Effects of steroid hormones on total brain Na(+)-k+ ATPase activity in Oreochromis mossambicus. Indian Journal of Experimental Biology. 2004 Mar; 42(3): 283-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57536
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weighten_US
dc.subject.meshBrain --drug effectsen_US
dc.subject.meshCorticosterone --pharmacologyen_US
dc.subject.meshDactinomycin --pharmacologyen_US
dc.subject.meshDiethylstilbestrol --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFishesen_US
dc.subject.meshHydrocortisone --pharmacologyen_US
dc.subject.meshProgesterone --pharmacologyen_US
dc.subject.meshPuromycin --pharmacologyen_US
dc.subject.meshSodium-Potassium-Exchanging ATPase --metabolismen_US
dc.subject.meshSteroids --pharmacologyen_US
dc.subject.meshTestosterone --pharmacologyen_US
dc.subject.meshTilapiaen_US
dc.titleEffects of steroid hormones on total brain Na(+)-k+ ATPase activity in Oreochromis mossambicus.en_US
dc.typeJournal Articleen_US
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