Phytochemical Composition and Biochemical Studies of the Aqueous Leaf Extracts of Brillantaisia guianensis P. beauv on Alloxan Treated Wistar Albino Rats

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dc.contributor.authorChinedu, Kalu E.en_US
dc.contributor.authorOnyeike, Eugene N.en_US
dc.contributor.authorIkewuchi, Catherine C.en_US
dc.date.accessioned2020-05-05T07:04:27Z
dc.date.available2020-05-05T07:04:27Z
dc.date.issued2019-10
dc.description.abstractThe present study was carried out on the phytochemical composition and biochemical studies oftheleafextract ofBrillantaisia guinensis peuvon alloxan treated Wistar albinorats.The experimental rats were administered with 80mg/kgbodyweight of alloxan,viathetailvein.After five days treatment with alloxan, thetreatment with the extractscommenced. Extracts wereadministeredorallyat100,200and 300mg/kg bw(both tonormal andtreated rats) for twenty-one days.Metformin,which served as a standard drug was administered at50mg/kg. Chromatographicanalysisof thephytochemical content of the leaf extract, revealed the presence of flavonoids (30.7mg/100g), saponins(50.6mg/100g), phytosterol (6.22mg/100g), tannins (7.50mg/100g) and glycosides(29.3mg/100g). Comparedtotest and normalcontrol,the extractsdose-dependentlyand significantlylowered(P<0.05) plasmaglucose and triglycerides, during the experimental period. Thisstudy revealedthe presence of pharma cologically bioactive compounds inthelea fextract and showed that the leaf extract had a dose-dependent hypoglycemic and hypotriglyceridemic effect on the Wistaralbino rats. The findings suggest a likely protective role of the extracts against hyperglycemia and hypertriglyceridemia thereby useful in the treatment and management of diabetes mellitus, obesity and other related cardiovascular diseases.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Science, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria*en_US
dc.identifier.citationChinedu Kalu E., Onyeike Eugene N., Ikewuchi Catherine C.. Phytochemical Composition and Biochemical Studies of the Aqueous Leaf Extracts of Brillantaisia guianensis P. beauv on Alloxan Treated Wistar Albino Rats . International Journal of Biochemistry Research & Review. 2019 Oct; 27(4): 1-13en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200735
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume27en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2019/v27i430129en_US
dc.subjectBrillantaisia guianensis P. beauven_US
dc.subjecthypoglycaemicen_US
dc.subjecthypotriglyceridemiaen_US
dc.subjectphytochemicals, alloxan-induced diabetes mellitusen_US
dc.titlePhytochemical Composition and Biochemical Studies of the Aqueous Leaf Extracts of Brillantaisia guianensis P. beauv on Alloxan Treated Wistar Albino Ratsen_US
dc.typeJournal Articleen_US
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