Oxidative Stress Markers in Children with Autism Spectrum Disorders.

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dc.contributor.authorGonzález-Fraguela, María Elena
dc.contributor.authorHung, Mei-Li Diaz
dc.contributor.authorVera, Hector
dc.contributor.authorMaragoto, Carlos
dc.contributor.authorNoris, Elena
dc.contributor.authorBlanco, Lisette
dc.contributor.authorReynaldo, Galvizu
dc.contributor.authorMaria, Robinson
dc.date.accessioned2015-08-31T11:50:38Z
dc.date.available2015-08-31T11:50:38Z
dc.date.issued2013-04
dc.description.abstractAims: The etiology of autism spectrum disorders (ASD) remains elusive, but oxidative stress has been suggested to play a pathological role. The understanding of the potential role of oxidative stress in the etiopathogenesis of autism would be very useful for earlier clinical, therapeutic or preventive strategies. Sample: To evaluate the redox status, we quantified the activity of the antioxidant enzyme catalase (CAT), glutathione concentration (GSH) and markers of damage to biomolecules, malonyldialdehyde (MDA) and 8–hydroxy-2deoxyguanosine (8OHdG) in peripheral blood samples. Place and Duration of Study: Sample: Department of Neuropediatrics and Technology Science Division. International Center for Neurological Restoration (CIREN), Havana, Cuba. May 2011- June 2012. Methodology: We included 45 children with autism (36 males and 9 females, age-range from 3 to 11 years). 42 children of the same age were selected as a control group. The diagnosis of autism was made based on the criteria of autistic disorders as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) (American Psychiatric Association, 1994). Results: The total GSH content in autistic patients was significantly lower compared with the control group (0.24 ± 0.162 vs. 0.94 ± 0.115, respectively, p ≤ 0.001). Higher serum CAT, MDA and 8OHdG levels were found in children with autism compared with controls (CAT, 2.836 ± 0.479 vs. 0.689 ± 0.157, p ≤ 0.001; MDA 8.6 ± 0.5 vs. 1.76 ± 0.33 p ≤ 0.001, and 8OHdG 13.134 ± 1.33 vs.1.46 ± 0.326, p ≤ 0.001). Conclusion: The present study supports the notion that oxidative stress is associated with autism, but additional researches are needed to investigate how it may contribute to autistic pathophysiology and these studies are currently in progress.en_US
dc.identifier.citationGonzález-Fraguela María Elena, Hung Mei-Li Diaz, Vera Hector, Maragoto Carlos, Noris Elena, Blanco Lisette, Reynaldo Galvizu, Maria Robinson. Oxidative Stress Markers in Children with Autism Spectrum Disorders. British Journal of Medicine and Medical Research. 2013 Apr-Jun; 3(2): 307-317.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162827
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/848en_US
dc.subjectAutismen_US
dc.subjectcatalaseen_US
dc.subjectglutathioneen_US
dc.subjectmalonyldialdehydeen_US
dc.subjectoxidative stress and 8-hydroxy-2-deoxyguanosineen_US
dc.titleOxidative Stress Markers in Children with Autism Spectrum Disorders.en_US
dc.typeArticleen_US
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