Surveillance for endometrial cancer in postmenopausal breast cancer patients taking tamoxifen.

dc.contributor.authorSinawat, Supaten_US
dc.contributor.authorChiyabutra, Taweesilpen_US
dc.contributor.authorKleabkaew, Pilaiwanen_US
dc.date.accessioned2009-05-27T17:37:09Z
dc.date.available2009-05-27T17:37:09Z
dc.date.issued2003-08-20en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractOBJECTIVES: To determine the prevalence of endometrial thickening and endometrial pathologies in postmenopausal breast cancer patients taking tamoxifen. MATERIALS AND METHODS: A total of 37 postmenopausal breast cancer patients receiving 20 microg/day of tamoxifen treatment for at least 6 months at Srinagarind hospital were included in the study. Thorough history taking and physical examination as well as transvaginal ultrasonography were conducted for all patients. Fractional curettage was carried out in those whose endometrial thickness was found to be greater than 5 mm. RESULTS: Among 37 patients included in this study, the mean age was 56.35 years. The mean body weight and mean body mass index was 60.88 kg and 26.03 kg/m(2), respectively. The majority of patients (75.68%) had stage II disease. The mean + SD of endometrial thickness found in this study was 7.53 + 5.16 mm. The prevalence of thickened endometrium (defined as ET > 5mm from TVS) was 59.46%. Among the 19 patients for whom fractional curettage was conducted, the majority (73.69%) exhibited inadequate endometrium for evaluation. Atrophic endometrium and other unremarkable changes were found in 21.05% of patients and it is important to note that endometrial adenocarcinoma was detected in 1 case (5.26%). CONCLUSIONS: The prevalence of thickened endometrium in postmenopausal breast cancer patients taking tamoxifen found in this study was extraordinarily high. These is, however, a discrepancy between the value and that for endometrial abnormalities detected histologically.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, 40002, Thailand. sisupat@kku.ac.then_US
dc.identifier.citationSinawat S, Chiyabutra T, Kleabkaew P. Surveillance for endometrial cancer in postmenopausal breast cancer patients taking tamoxifen. Asian Pacific Journal of Cancer Prevention. 2003 Aug-Dec; 4(4): 327-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37530
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAntineoplastic Agents, Hormonal --adverse effectsen_US
dc.subject.meshBreast Neoplasms --drug therapyen_US
dc.subject.meshEndometrial Neoplasms --chemically induceden_US
dc.subject.meshEndometrium --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPostmenopauseen_US
dc.subject.meshTamoxifen --adverse effectsen_US
dc.titleSurveillance for endometrial cancer in postmenopausal breast cancer patients taking tamoxifen.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description: