Xanthogranulomatous inflammatory lesions: a 10-year clinicopathological study in a teaching hospital.
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Date
2014-07
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Abstract
Objective: To review the demographic, clinical and histomorphological aspects of xanthogranulomatous
inflammation (XGI) in different organs. Material and methods: All
the cases diagnosed as XGI by histopathology from the specimens received in the
department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India
over the period of 10 years from January 2001 to December 2010 were included in the
study. All the available data including age, sex, organ of involvement, association with stone
etc. were collected and analyzed retrospectively. All the slides were reviewed. The results
were recorded and ana-lyzed. Results: A total of 98 cases of XGI were diagnosed out of a
total of 9755 specimens received, constituted by 5382 of gall bladder, 4298 of appendix, 41
of kidney and 24 of tube and tubo-ovarian mass making an overall incidence of 1%. The
incidence of XGI in kidney was 12.19%, followed by 4.16% in tube and tubo-ovarian
mass, 1.5% in gall bladder and 0.25% in appendix. Maximum number of cases were in
the age group of 41-50 years with 33.67%. The female to male sex ratio was 2.5: 1. 90.2%
cases in kidney and 86.6 % in gall bladder were associated with calculi. One case was
associated with adenocarcinoma of gall bladder. Conclusion: Xanthogranulomatous
inflammation which often mimics malignancy clinically and morphologically, is
increasingly recognized in different anatomic locations. An accurate diagnosis will relieve
the psychological panic of suspected malignancy and prevent the patient from aggressive
treatment.
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Keywords
xanthogranulomatous inflammation, histopathology, lipid-laden macrophages, malignancy
Citation
Laishram S, Shimray R, Pukhrambam GD, Sarangthem B, Sharma A B. Xanthogranulomatous inflammatory lesions: a 10-year clinicopathological study in a teaching hospital. Bangladesh Journal of Medical Science. 2014; 13(3): 302-305.