Comparative Antidiabetic Potential Assessment Of Herbal Formulation Of Gymnemic Acid And Curcumin

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dc.contributor.authorShukla, A.en_US
dc.contributor.authorSachan, M.en_US
dc.contributor.authorBigoniya, P.en_US
dc.date.accessioned2020-10-16T07:49:57Z
dc.date.accessioned2024-09-24T11:51:40Z
dc.date.available2020-10-16T07:49:57Z
dc.date.available2024-09-24T11:51:40Z
dc.date.issued2019-05
dc.description.abstractStandardization of polyherbal formulations with respect to bioactive phytocompounds is the need of the time for registration and marketing authorization in developed countries. This has prompted to prepare and evaluate a standardized bioactive phyotcompounds conintaining formulation. The study aims at development and screening of a standardized antidiabetic suspension containing active isolated phytoconstituents targeting better therapeutic effect with reduced bioburden. Suspension of isolated gymnemic acid and curcumin (GCS) was prepared, evaluated and authenticated by TLC and HPTLC. Antidiabetic efficacy of GCS was screened against alloxan induced diabetes on rats following 28 days of treatment comparative to Hyponidd tablet and Madhumehari granules. Body weight, relative organ weight, blood glucose, cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) level was measured. The formulation having pH 6.0, refractive index 1.41 and 45.58 mg/ml total solid content showed high alcohol and water soluble extractive value. The GCS treatment normalized liver and kidney weight, decreased body weight gain, TC, TG, LDL and VLDL level along with an increase in HDL level. Study outcome signifies similar antidiabetic potential of standardized formulation GCS compared to marketed Polyherbal formulation with antihyperlipidemic activity signifying as a promising natural and safe remedy for the prevention of diabetic complications.en_US
dc.identifier.affiliationsAmity Institute of Pharmacy, Amity University, Near Malhaur Railway Station, Gomti Nagar Extn, Lucknow, Utter Pradesh, Indiaen_US
dc.identifier.affiliationsRadharaman College of Pharmacy, Radharaman Group of Institutes, Ratibad, Bhopal, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDSKM College of Pharmacy, RKDF University, Gandhi Nagar, Bhopal, Madhya Pradesh, Indiaen_US
dc.identifier.citationShukla A., Sachan M., Bigoniya P.. Comparative Antidiabetic Potential Assessment Of Herbal Formulation Of Gymnemic Acid And Curcumin. International Journal of Pharmaceutical Sciences and Drug Research. 2019 May; 11(3): 98-104en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206229
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2019.110305en_US
dc.subjectGymnemic aciden_US
dc.subjectCurcuminen_US
dc.subjectPolyherbal formulationen_US
dc.subjectantidiabeticen_US
dc.subjectantihyperlipidemicen_US
dc.titleComparative Antidiabetic Potential Assessment Of Herbal Formulation Of Gymnemic Acid And Curcuminen_US
dc.typeJournal Articleen_US
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