alpha-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats.

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dc.contributor.authorKumar, M Satishen_US
dc.contributor.authorPrashanth, K V Harishen_US
dc.date.accessioned2009-05-28T14:12:22Z
dc.date.available2009-05-28T14:12:22Z
dc.date.issued2004-03-06en_US
dc.description.abstractalpha-Lipoic acid treatment (100 mg/kg/day for 2 weeks after 6 weeks of untreated diabetes) of streptozotocin diabetic rats partially but significantly reversed both reduced contractile response of distal colon to acetylcholine and delayed transit of charcoal meal in small intestine compared to diabetic control. These effects of alpha-Lipoic acid were associated with complete reversal of diabetes induced increased plasma lipid peroxidation level. alpha-Lipoic acid had no effect on any of the parameters measured in non-diabetic rats. These findings demonstrate contribution of oxidative stress in the development of physiological changes of gut in diabetes.en_US
dc.description.affiliationDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore 570 006, India. mskgowda@yahoo.comen_US
dc.identifier.citationKumar MS, Prashanth KV. alpha-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats. Indian Journal of Experimental Biology. 2004 Mar; 42(3): 279-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60407
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetylcholine --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshBody Weighten_US
dc.subject.meshColon --drug effectsen_US
dc.subject.meshDiabetes Mellitus, Experimentalen_US
dc.subject.meshFemaleen_US
dc.subject.meshIntestine, Small --metabolismen_US
dc.subject.meshIntestines --drug effectsen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStreptozocinen_US
dc.subject.meshThioctic Acid --pharmacologyen_US
dc.titlealpha-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats.en_US
dc.typeJournal Articleen_US
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