CD4 count, viral load and parasite density of HIV positive individuals undergoing malaria treatment with dihydroartemisinin in Benin City, Edo state, Nigeria.

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dc.contributor.authorTatfeng, Y Men_US
dc.contributor.authorIhongbe, J Cen_US
dc.contributor.authorOkodua, Men_US
dc.contributor.authorOviasogie, Een_US
dc.contributor.authorIsibor, Jen_US
dc.contributor.authorTchougang, Sen_US
dc.contributor.authorTambo, Een_US
dc.contributor.authorOtegbeye, Ten_US
dc.date.accessioned2007-06-29en_US
dc.date.accessioned2009-06-02T15:47:02Z
dc.date.available2007-06-29en_US
dc.date.available2009-06-02T15:47:02Z
dc.date.issued2007-06-29en_US
dc.description.abstractBACKGROUND & OBJECTIVES: A prospective study on 72 HIV infected and 33 HIV negative individuals undergoing malaria treatment with dihydroartemisinin (Cotecxin) was undertaken to compare CD4 cells count, viral load and parasite density at two time-points, a baseline visit and a 9-day post-treatment visit. METHODS: CD4 count and viral load of the subjects were estimated using Dynabeads T4-T8 Quantification Protocol (Dyneal Biotech, Norway) and Amplicor HIV-1 Monitor Test respectively (Roche, United Kingdom). RESULTS: There was a significant decrease in CD4 count at 9-day post-treatment when compared with baseline value (p < 0.05) in HIV infected individuals with CD4 < or =200 cells/microl. Also, the 9-day post-treatment viral load value was statistically higher than the baseline value (p < 0.05). In HIV positive patients with CD4 >200 cells/microl, a marked significant increase was obtained when the mean viral load at baseline was compared to the 9-day post-treatment visit value (p <0.05). The mean parasite density in HIV positive subjects was statistically higher when compared to that of HIV negative individuals at baseline and 9-day post-treatment (p < 0.05). INTERPRETATION & CONCLUSION: The study as such may not confirm the impact of malaria infection on progression to AIDS, incorporating effective malaria control in HIV management programmes may improve tremendously the quality of life of HIV infected individuals.en_US
dc.description.affiliationLahor Public Health and Research Centre, Benin City, Nigeria/Igbinedion University, Okada. youtchou@yahoo.comen_US
dc.identifier.citationTatfeng YM, Ihongbe JC, Okodua M, Oviasogie E, Isibor J, Tchougang S, Tambo E, Otegbeye T. CD4 count, viral load and parasite density of HIV positive individuals undergoing malaria treatment with dihydroartemisinin in Benin City, Edo state, Nigeria. Journal of Vector Borne Diseases. 2007 Jun; 44(2): 111-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/117981
dc.language.isoengen_US
dc.source.urihttps://www.mrcindia.org/journal/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntimalarials --therapeutic useen_US
dc.subject.meshArtemisinins --therapeutic useen_US
dc.subject.meshCD4 Lymphocyte Counten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --blooden_US
dc.subject.meshHIV-1en_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMalaria --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNigeriaen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSesquiterpenes --therapeutic useen_US
dc.subject.meshUrban Healthen_US
dc.subject.meshViral Loaden_US
dc.titleCD4 count, viral load and parasite density of HIV positive individuals undergoing malaria treatment with dihydroartemisinin in Benin City, Edo state, Nigeria.en_US
dc.typeJournal Articleen_US
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