Evaluation of Androgen Receptor in Breast Carcinoma and its Correlations with Er, Pr, Her2/Neu, Triple Negative Receptor Status and Clinical Parameters

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dc.contributor.authorSaxena, Avanish Kumaren_US
dc.contributor.authorAgarwal, Mayanken_US
dc.contributor.authorSinghal, Juhien_US
dc.contributor.authorGupta, Amritaen_US
dc.date.accessioned2019-11-16T07:25:50Z
dc.date.available2019-11-16T07:25:50Z
dc.date.issued2017-07
dc.description.abstractBackground: Breast cancer is the second most common malignancy in Indian women. Among the members of the steroid receptor superfamily the role of estrogen and progesterone receptors (ER and PR) is well established in breast cancer in predicting the prognosis and management of therapy, however, little is known about the clinical significance of androgen receptor (AR) in breast carcinogenesis. The present study was aimed to evaluate the expression of AR in breast cancer and to elucidate its clinical significance by correlating it with other hormonal receptors and clinical parameters. Methods: It was a prospective study which include 30 patients of histopathologically proven breast cancer  admitted to department of surgery at  S.N Medical College Agra .Expression of AR, ER, PR, HER2/ neu receptor  by immunohistochemistry (IHC) and clinical parameters were studied. Results: AR expression is related to ER(P<0.015), PR(p<0.008) and triple negative breast cancer patients (p <0.008). There is significant correlation between AR and menopausal status(p<0.006) while  no significant correlation was found with age and parity. Conclusions: Since there is significant association of AR  in triple negative and post-menopausal women so we can say that AR expression possibly help in confirming their predictive role for therapeutic response in breast cancer patientsen_US
dc.identifier.affiliationsProfessor, Department of Surgery S.N. Medical College, Agraen_US
dc.identifier.affiliationsSenior Resident, Department of Anaesthesia, S.N Medical College, Agra, UP, India.en_US
dc.identifier.affiliationsAssociate Professor, Department of Surgery S.N. Medical College, Agraen_US
dc.identifier.affiliationsAssistant Professor, Department of Anaesthesia SN Medical College, Agraen_US
dc.identifier.citationSaxena Avanish Kumar, Agarwal Mayank, Singhal Juhi, Gupta Amrita. Evaluation of Androgen Receptor in Breast Carcinoma and its Correlations with Er, Pr, Her2/Neu, Triple Negative Receptor Status and Clinical Parameters. International Archives of BioMedical and Clinical Research. 2017 Jul-Sep; 3(3): 48-51en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184353
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber3en_US
dc.relation.volume3en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2017.3.3.13en_US
dc.subjectAndrogen Receeptoren_US
dc.subjectEstrogen Receptoren_US
dc.subjectTriple Negativeen_US
dc.subjectBreast Canceren_US
dc.titleEvaluation of Androgen Receptor in Breast Carcinoma and its Correlations with Er, Pr, Her2/Neu, Triple Negative Receptor Status and Clinical Parametersen_US
dc.typeJournal Articleen_US
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