Study of dexmedetomidine as an intrathecal adjuvant to ropivacaine for hemodynamic stability and for postoperative analgesia

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dc.contributor.authorAmbati, Swethaen_US
dc.contributor.authorB, Mukesh Kumaren_US
dc.date.accessioned2019-12-02T10:00:04Z
dc.date.available2019-12-02T10:00:04Z
dc.date.issued2017
dc.description.abstractBackground: Various adjuvants that can be added to local anesthetics and administered in central neuraxial blockade are Opioids, α2 agonists, benzodiazepines. Knowledge and use of adjuvant drug therapy has rendered neuraxial analgesia more effective in the management of both acute and chronic pain conditions. α-2 adrenergic agonists have both analgesic and sedative properties when used as adjuvant in regional anaesthesia. Aim: To study the effects of intrathecal dexmedetomidine added to ropivacaine for surgeries under spinal anesthesia. Materials and methods: Clinical study conducted on 50 patients of ASA PS 1 and 2 in the age group of 18-50 years of either sex posted for elective lower limb orthopaedic and lower abdominal surgeries under spinal anaesthesia. Results: Subjects among the age groups and the mean age of study population was 40 years (SD: ±11.5). 66% (n=33) of study population were male and 34% (n=17) were female. Most of the study population had healthy BMI. 76% (n= 38) of subjects belonged to ASA grade 1 and 34% (n=12) subjects belonged to ASA grade 2. The average duration of surgery was 94.4 min ± 34.4 min. Level of sensory block was T6 in 24 (48%) of subjects, T4 in 17 (34%) of subjects, T8 in 6 (12%) and T2 in 3 (6%) of subjects. The mean duration for onset of Sensory block was 4.12 minutes (SD: ± 1.69) and the mean duration for onset of motor block was 10.12 minutes (SD: ± 2.89). Hypotension was Swetha Ambati, Mukesh Kumar B. Study of dexmedetomidine as an intrathecal adjuvant to ropivacaine for hemodynamic stability and for postoperative analgesia. IAIM, 2017; 4(11): 27-36. Page 28 observed in 3 patients after SAB (Fall in SBP > 20%) after 4 to 6 min. The mean RSS was 2.08 with SD 0.27. Side effects observed were mainly hypotension, nausea and shivering. Conclusions: 5 microgram dexmedetomidine is alternative as an adjuvant to spinal ropivacaine in surgical procedures. It has excellent quality of postoperative analgesia with minimal side effects.en_US
dc.identifier.affiliationsMICU Interventionist, Department of Anesthesiology and Critical Care Medicine, Institute of Child Health, Niloufer Hospital for Women and Children, Osmania Medical College, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsAnesthetist, Department of Anesthesiology and Critical Care Medicine, Care Hospitals, Banjara hills, Hyderabad, Telangana, India, shwetha.ambat@gmail.comen_US
dc.identifier.citationAmbati Swetha, B Mukesh Kumar. Study of dexmedetomidine as an intrathecal adjuvant to ropivacaine for hemodynamic stability and for postoperative analgesia. International Archives of Integrated Medicine. 2017 Nov; 4(11): 27-36en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186732
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber11en_US
dc.relation.volume4en_US
dc.subjectDexmedetomidineen_US
dc.subjectIntrathecalen_US
dc.subjectRopivacaineen_US
dc.subjectHemodynamic stabilityen_US
dc.subjectPost-operativeen_US
dc.subjectAnalgesiaen_US
dc.titleStudy of dexmedetomidine as an intrathecal adjuvant to ropivacaine for hemodynamic stability and for postoperative analgesiaen_US
dc.typeJournal Articleen_US
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