Anti-inflammatory and antioxidant potential of Artemisia dracunculus L. aqueousextract against acetic acid induced ulcerative colitis in male Wistar rats

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dc.contributor.authorKalhor, Priyaen_US
dc.contributor.authorMohammadzadeh, Mehdien_US
dc.contributor.authorAbtahi Froushani, Seyyed Meysamen_US
dc.date.accessioned2023-08-09T06:21:17Z
dc.date.available2023-08-09T06:21:17Z
dc.date.issued2023-01
dc.description.abstractUlcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD) which is increasing worldover due to modern life style. Patients with UC are prone to develop colorectal cancer. While the disease severity decides the treatment option, researchers look towards herbal medicines with anti-inflammatory properties for minimal or nil side effects. Artemisia dracunculus L., commonly called Tarragon, is a medicinal herb used in traditional Asian medicine mainly in Iran, India, Pakistan and Azerbaijan due to its special compounds. In this study, we tried to elucidate the effects of aqueous extract of tarragon on acetic acid induced ulcerative colitis (UC) in rats. Male Wistar rats were grouped into four groups of eight each viz., control; experimental control (UC was induced via luminal instillation of 4% acetic acid); and UC induced + aqueous tarragon extract (100 mg/kg) or prednisolone (2 mg/kg) orally for ten consecutive days. Tissue specimens were collected after the experimental period for evaluation of caspase-3 and cyclooxygenase-2 (COX-2) expression by immunohistochemistry. Real-time PCR was used to monitor the levels of IL-1, IL-6 and TNF-? in colonic homogenates. Moreover, the levels of myeloperoxidase, nitric oxide and total antioxidant capacity were measured in colonic homogenates. The results showed that both treatment regimens could similarly reduce the severity of disease symptoms. Treatment with aqueous extract of tarragon caused a better improvement (P <0.05) in the levels of myeloperoxidase enzyme, and total antioxidant capacity of colonic homogenates compared to prednisolone. Nevertheless, the levels of the expression of caspase-3, and COX-2 and TNF-? were reduced in UC rats received prednisolone more than UC rats received aqueous extract of tarragon. The was no statistical difference in the levels of nitric oxide, IL-1 and IL-6 between UC rats received tarragon extract or prednisolone. Overall, these findings suggest that the aqueous extract of tarragon is a promising strategy to control ulcerative colitis. Aqueous extract can also be used as an anti-inflammatory and immune system stimulant in conditions where the immune system is damaged.en_US
dc.identifier.affiliationsDepartment of Biologyen_US
dc.identifier.affiliationsDepartment of Microbiology, Faculty of Veterinary Medicine, Urmia University, West Azaarbayjan, Urmia, Iranen_US
dc.identifier.citationKalhor Priya, Mohammadzadeh Mehdi, Abtahi Froushani Seyyed Meysam. Anti-inflammatory and antioxidant potential of Artemisia dracunculus L. aqueousextract against acetic acid induced ulcerative colitis in male Wistar rats. Indian Journal of Experimental Biology. 2023 Jan; 61(1): 42-50en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222593
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber1en_US
dc.relation.volume61en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v61i01.41130en_US
dc.subjectCaspase-3en_US
dc.subjectColorectal canceren_US
dc.subjectCyclooxygenase-2en_US
dc.subjectDisease activity indexen_US
dc.subjectEstragonen_US
dc.subjectInflammatory bowel disease (IBD)en_US
dc.subjectTumor necrosis factoren_US
dc.subjectPro-inflammatory cytokinesen_US
dc.subjectTarragonen_US
dc.titleAnti-inflammatory and antioxidant potential of Artemisia dracunculus L. aqueousextract against acetic acid induced ulcerative colitis in male Wistar ratsen_US
dc.typeJournal Articleen_US
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