Assessment of arterial stiffness in stable patients of chronic obstructive pulmonary disease: a prospective case control study

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dc.contributor.authorKumar, Sandeepen_US
dc.contributor.authorGupta, D. D.en_US
dc.contributor.authorSarkar, Malayen_US
dc.contributor.authorRameshen_US
dc.date.accessioned2020-04-23T07:52:33Z
dc.date.available2020-04-23T07:52:33Z
dc.date.issued2018-11
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and represents a substantial socioeconomic burden. Co-morbidities are more in COPD patients. Cardiovascular disease is one of the co-morbid conditions in COPD. Arterial stiffness has a strong predictive value for cardiovascular events, which can be assessed non-invasively. Various predictors of arterial stiffness between stable COPD patients and healthy volunteers were measured and compared.Methods: COPD patients attending pulmonary medicine outpatient services were screened for enrolment. It was a prospective case control study with enrolment of fifty COPD stable cases and fifty healthy control, who were matched for their age and sex. All eligible participants were subjected to focused history and physical examination as per structured questionnaire, followed by spirometric examination, periscope test, arterial blood gas analysis and six- minute walk test (6MWT).Results: Increased arterial stiffness was observed in COPD patients over a wide range of severity of airway obstruction. Distance walked in 6MWT and spirometric values were significantly lower in COPD group as compared to healthy group.Conclusions: It was concluded that vascular changes, which are predictive of cardiovascular disease remain as cardiovascular risks in mild or early lung disease. A strong relationship between COPD, systemic inflammation, arterial stiffness and cardiovascular disease had been found which needs to be explored further. It was finally concluded that targeted therapeutic approach has broad aspect in reducing cardiovascular risks and has potential for improved prognosis in COPD.en_US
dc.identifier.affiliationsDepartment of Pharmacology, I.G.M.C., Shimla, Himachal Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, I.G.M.C., Shimla, Himachal Pradesh, Indiaen_US
dc.identifier.citationKumar Sandeep, Gupta D. D., Sarkar Malay, Ramesh. Assessment of arterial stiffness in stable patients of chronic obstructive pulmonary disease: a prospective case control study. International Journal of Basic & Clinical Pharmacology. 2018 Nov; 7(11): 2078-2085en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199904
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184314en_US
dc.subjectArterial stiffnessen_US
dc.subjectCOPDen_US
dc.subjectPeriscope analysisen_US
dc.titleAssessment of arterial stiffness in stable patients of chronic obstructive pulmonary disease: a prospective case control studyen_US
dc.typeJournal Articleen_US
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