Prevalence of Red Cell Alloantibodies Among Cohort of Healthy Blood Donors in a Tertiary Care Hospital � A Step Towards Blood Safety

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dc.contributor.authorGhotra, Bableen Kauren_US
dc.contributor.authorGupta, Soniaen_US
dc.contributor.authorKumar, Rajeshen_US
dc.date.accessioned2025-05-09T11:04:41Z
dc.date.available2025-05-09T11:04:41Z
dc.date.issued2024-09
dc.description.abstractBackground: Red cell antibody screening should be an imperative element in assuring transfusion safety. The aim of the study is to screen healthy donors for clinically significant alloantibodies to prevent risk of adverse reactions in transfusion recipients. Methods: This prospective cohort study was carried out for a period of one year. Antibody screening of all blood donors was performed as a routine on an automated immunohaematology platform using Immucor Capture R-ready screen (pooled O cells) Galileo Neo (Immucor Inc. Norcross GA, USA). Positive screen was further investigated to identify specificity by 3 cell and 11 cell panel. Results: Red cell alloantibodies screening was conducted on 26,772 blood samples of healthy donors of which 26,129 (94.9%) were male and 4 (5.1%) were female. The donors were screened from both indoor (blood centre) 79.7% and outdoor collection (camp) 20.3%. 79 (0.3%), were found to be positive for antibody screening. Mean age of donors showing positive screen was 35.14�67 years (20-60 years). Mean weight of the donor was 81.59�.19. On antibody identification 48 (61%) had alloantibodies, 4 (5.1%) warm autoantibodies while 27 (34.2%) were inconclusive. The most common alloantibody identified was Anti M 28 (35.4%), Anti P1 5 (6.3%) followed by Anti E 3 (3.8%). The result showed a high prevalence of RBC alloantibodies in females than males (0.6% / 0.2%). Conclusion: Type and Screen protocol should be followed for detection of alloantibodies against red cells antigens which adds as an additional layer of safe blood transfusion.en_US
dc.identifier.affiliationsSenior Resident, Department of Transfusion Medicine, PGIMER, Chandigarhen_US
dc.identifier.affiliationsAssociate Professor, Department of Immunohaematology and Blood Transfusion, Dayanand Medical College and Hospital, Ludhianaen_US
dc.identifier.affiliationsProfessor, Department of Immunohaematology and Blood Transfusion, Dayanand Medical College and Hospital, Ludhianaen_US
dc.identifier.citationGhotra Bableen Kaur, Gupta Sonia, Kumar Rajesh . Prevalence of Red Cell Alloantibodies Among Cohort of Healthy Blood Donors in a Tertiary Care Hospital � A Step Towards Blood Safety. International Journal of Contemporary Medical Research. 2024 Sep; 11(9): 1-5en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246166
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber9en_US
dc.relation.volume11en_US
dc.source.urihttps://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_3746_v2.pdfen_US
dc.subjectAntibody Screeningen_US
dc.subjectAutoantibodiesen_US
dc.subjectAlloantibodies.en_US
dc.titlePrevalence of Red Cell Alloantibodies Among Cohort of Healthy Blood Donors in a Tertiary Care Hospital � A Step Towards Blood Safetyen_US
dc.typeJournal Articleen_US
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