Prevalence of Red Cell Alloantibodies Among Cohort of Healthy Blood Donors in a Tertiary Care Hospital � A Step Towards Blood Safety
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Date
2024-09
Journal Title
Journal ISSN
Volume Title
Publisher
International Society for Contemporary Medical Research
Abstract
Background: Red cell antibody screening should be an imperative element in assuring transfusion safety. The aim of the study is to screen healthy donors for clinically significant alloantibodies to prevent risk of adverse reactions in transfusion recipients. Methods: This prospective cohort study was carried out for a period of one year. Antibody screening of all blood donors was performed as a routine on an automated immunohaematology platform using Immucor Capture R-ready screen (pooled O cells) Galileo Neo (Immucor Inc. Norcross GA, USA). Positive screen was further investigated to identify specificity by 3 cell and 11 cell panel. Results: Red cell alloantibodies screening was conducted on 26,772 blood samples of healthy donors of which 26,129 (94.9%) were male and 4 (5.1%) were female. The donors were screened from both indoor (blood centre) 79.7% and outdoor collection (camp) 20.3%. 79 (0.3%), were found to be positive for antibody screening. Mean age of donors showing positive screen was 35.14�67 years (20-60 years). Mean weight of the donor was 81.59�.19. On antibody identification 48 (61%) had alloantibodies, 4 (5.1%) warm autoantibodies while 27 (34.2%) were inconclusive. The most common alloantibody identified was Anti M 28 (35.4%), Anti P1 5 (6.3%) followed by Anti E 3 (3.8%). The result showed a high prevalence of RBC alloantibodies in females than males (0.6% / 0.2%). Conclusion: Type and Screen protocol should be followed for detection of alloantibodies against red cells antigens which adds as an additional layer of safe blood transfusion.
Description
Keywords
Antibody Screening, Autoantibodies, Alloantibodies.
Citation
Ghotra Bableen Kaur, Gupta Sonia, Kumar Rajesh . Prevalence of Red Cell Alloantibodies Among Cohort of Healthy Blood Donors in a Tertiary Care Hospital � A Step Towards Blood Safety. International Journal of Contemporary Medical Research. 2024 Sep; 11(9): 1-5