Anti-inflammatory Activity of Isolated Flavonoid from Sida cordifolia Leaves Extract

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dc.contributor.authorPadhy, Ipsaen_US
dc.contributor.authorDash, Prajnanjalien_US
dc.contributor.authorSahu, Ram Kumaren_US
dc.contributor.authorSaha, Gauraven_US
dc.date.accessioned2020-09-24T07:52:50Z
dc.date.available2020-09-24T07:52:50Z
dc.date.issued2019-08
dc.description.abstractThe anti-inflammatory activities of Sida cordifolia leave extract were scientifically stated. However, no report has yet been published about the active component responsible for anti-inflammatory activity of Sida cordifolia leaves extract. It was intended to isolate the flavonoids from the Sida cordifolia leaves extract and investigated its anti-inflammatory efficacy. Petroleum ether and ethanol extract were extracted out from the powdered of leaves. The phytochemical study was done for both extracts. The in vitro antioxidant activity was performed on ethanol extract on different models. The column chromatography was used for the isolation of flavonoid from ethanol extract, and further anti-inflammatory potency of the isolated compound was investigated. The phytochemical study indicates flavonoids and polyphenol were present in ethanol extract. The higher antioxidant activity was observed in ethanol extract from findings of antioxidant study. The isolated flavonoids exhibited Rf value of 0.46 on solvent ratio of chloroform: methanol (1:1), which was similar to standard quercetin. The significant anti-inflammatory activity was found for isolated flavonoid against carrageenan-induced edema and cotton pellet-induced granuloma in experimental animals. The findings confirmed that the flavonoid present in the Sida cordifolia demonstrated anti-inflammatory activity.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, College of Pharmaceutical Sciences, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacy, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur, Indiaen_US
dc.identifier.citationPadhy Ipsa, Dash Prajnanjali, Sahu Ram Kumar, Saha Gaurav. Anti-inflammatory Activity of Isolated Flavonoid from Sida cordifolia Leaves Extract. International Journal of Medical Research & Health Sciences. 2019 Aug; 8(8): 75-81en_US
dc.identifier.issn2319-5886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205097
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber8en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmrhs.com/abstract/antiinflammatory-activity-of-isolated-flavonoid-from-sida-cordifolia-leaves-extract-18761.htmlen_US
dc.subjectSida cordifoliaen_US
dc.subjectFlavonoidsen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectCarrageenan-induced edemaen_US
dc.subjectCotton pellet-induced granulomaen_US
dc.titleAnti-inflammatory Activity of Isolated Flavonoid from Sida cordifolia Leaves Extracten_US
dc.typeJournal Articleen_US
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