A short term evaluation of effect on serum urea, creatinine and potassium levels with use of angiotensin II receptor blockers (olmesartan or telmisartan) in stage 1 hypertensive patients

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dc.contributor.authorGupta, Varunen_US
dc.contributor.authorSingh, Poojaen_US
dc.date.accessioned2020-04-23T07:58:26Z
dc.date.available2020-04-23T07:58:26Z
dc.date.issued2019-10
dc.description.abstractBackground: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (ARBs) are being used as first line agents for the treatment of hypertension in haemodialysis patients as well as in the general population. Serious hyperkalemia is common in patients with end-stage renal disease, and is observed in about 10% of haemodialysis patients. Although many research have been done so far to compare the antihypertensive efficacy of ARBs, but such studies to evaluate the effect on serum urea, creatinine and potassium levels are not so common in North India region.Methods: In this open label, prospective, randomized study, we evaluated the effect on serum urea, creatinine and potassium levels with use of ARB’s (olmesartan or telmisartan) in stage 1 hypertensive patients (JNCVII). 60 patients were randomized in to two groups. The odd numbers will be allotted olmesartan 20 mg (group A) and even numbers to telmisartan 40 mg (group B). Impacts on serum urea, creatinine and potassium levels were evaluated after 12 weeks.Results: Our results indicates that there was no statistically significant alterations in mean serum creatinine, blood urea and in mean serum potassium levels compared to baseline within the two groups as well as when mean of both groups were compared, olmesartan showed a better reduction in blood pressure as compared to telmisartan.Conclusions: Olmesartan showed a better reduction in blood pressure with similar effects in biochemical parameters as telmisartan.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Government Medical College, Bharartpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Bharartpur, Rajasthan, Indiaen_US
dc.identifier.citationGupta Varun, Singh Pooja. A short term evaluation of effect on serum urea, creatinine and potassium levels with use of angiotensin II receptor blockers (olmesartan or telmisartan) in stage 1 hypertensive patients. International Journal of Basic & Clinical Pharmacology. 2019 Oct; 8(10): 2328-2333en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200384
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20194281en_US
dc.subjectOlmesartanen_US
dc.subjectTelmisartanen_US
dc.subjectMean serum creatinineen_US
dc.subjectBlood ureaen_US
dc.subjectMean serum potassiumen_US
dc.titleA short term evaluation of effect on serum urea, creatinine and potassium levels with use of angiotensin II receptor blockers (olmesartan or telmisartan) in stage 1 hypertensive patientsen_US
dc.typeJournal Articleen_US
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