Profile of thyrotoxic patients presenting as pyrexia of unkown origin: An observational case study from a tertiary care hospital

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dc.contributor.authorAhmad Pala, Nen_US
dc.contributor.authorMohd, Aen_US
dc.contributor.authorBhoughal, Ben_US
dc.date.accessioned2020-09-24T07:54:02Z
dc.date.available2020-09-24T07:54:02Z
dc.date.issued2019-02
dc.description.abstractObjective: To study the profile of thyrotoxic patients evaluated for pyrexia of unknown origin (PUO). Methods: 25 patients, who were evaluated for pyrexia of unknown origin and found to have thyrotoxicosis as the cause for fever, were managed as per the recommended protocol and followed for 12 months. Results: All the patients were presumed to have infectious fever and had received antibiotics prior to diagnosis. Out of 25 patients, 20 (80%) had subacute thyroiditis (SAT) and 5 (20%) had hyperthyroidism (4 had Graves disease and 1 toxic adenoma). Patients with hyperthyroidism received thionamides and β- blockers. 50% patients with subacute thyroiditis received analgesics, 25% received steroids only and 25% received a combination of analgesics and steroids. Early-onset transient hypothyroidism occurred in 40% patients with SAT, permanent hypothyroidism was less common and only 15% of patients were receiving levothyroxine therapy after one year of follow-up. Conclusion: Thyrotoxicosis should always be included in the differential diagnosis while evaluation of patients with PUO. Most of the patients with thyrotoxicosis are wrongly misinterpreted as infectious PUO and given unnecessary antibiotics. Early-onset transient hypothyroidism is common in SAT compared to permanent hypothyroidism. Although, symptomatic relief is achieved with analgesics and steroids but does not prevent the development of hypothyroidism.en_US
dc.identifier.affiliationsDr. Nazir Ahmad Pala Lecturer, Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDr. Mohd Ashraf Assistant Professor, Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDr. Badrinath Bhoughal Associate Professor, Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.citationAhmad Pala N, Mohd A, Bhoughal B. Profile of thyrotoxic patients presenting as pyrexia of unkown origin: An observational case study from a tertiary care hospital. International Journal of Medical Research & Review. 2019 Feb; 7(1): 30-35en_US
dc.identifier.issn2320-8686
dc.identifier.issn2321-127X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205294
dc.languageenen_US
dc.publisherSiddharth Health Research and Social Welfare Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://ijmrr.medresearch.in/index.php/ijmrr/article/view/1032en_US
dc.subjectThyrotoxic PUOen_US
dc.subjectAcetylsalicylicen_US
dc.subjectCorticosteroidsen_US
dc.subjectPost-thyroiditis hypothyroidismen_US
dc.titleProfile of thyrotoxic patients presenting as pyrexia of unkown origin: An observational case study from a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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