Quantitative Analysis Of Pamabrom And Ibuprofen In Synthetic Mixture Using 1st Order Derivative Spectroscopy

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dc.contributor.authorPatel, P.en_US
dc.contributor.authorVasani, P.en_US
dc.contributor.authorMehta, B.en_US
dc.contributor.authorDetholia, K.en_US
dc.date.accessioned2020-09-24T08:01:18Z
dc.date.available2020-09-24T08:01:18Z
dc.date.issued2019-10
dc.description.abstractObjective: The preliminary goal was to develop and validate 1st order derivative spectroscopic method for quantitative analysis of Pamabrom (PAMA) which is a xanthine diuretic and ibuprofen (IBU) which is a non-steroidal anti-inflammatory agent from its synthetic mixture. Methods: Analytical method was developed on Shimadzu double beam spectrophotometer equipped with UV probe 2.42 as software using methanol as solvent. Quantification of PAMA was carried out at zero cross over point of IBU that is 291 nm and for IBU, it was achieved at 278 nm which is zero cross over point of PAMA. Method was validated according to ICH Q2 R1 guidelines. Results: Method showed a linear response in the range of 2-12 µg/ml of PAMA and 20-120 µg/ml of IBU. Method was found to be accurate with recovery between 99.7–100.9 % for PAMA and 100.3–100.7 % for IBU. The method was found to be accurate and precise for quantitative analysis of PAMA and IBU. Conclusion: The developed method was successfully validated as per ICH Q2 R1 guidelines and was successfully applied for quantitative analysis of a synthetic mixture of PAMA and IBU.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Quality Assurance, Smt. S. M. Shah Pharmacy College, Amsaran, Gujarat 387130en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Quality Assurance, Smt. S. M. Shah Pharmacy College, Amsaran, Gujarat 387130en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Quality Assurance, Smt. S. M. Shah Pharmacy College, Amsaran, Gujarat 387130en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Smt. S. M. Shah Pharmacy College, Amsaran, Gujarat 387130en_US
dc.identifier.citationPatel P., Vasani P., Mehta B., Detholia K.. Quantitative Analysis Of Pamabrom And Ibuprofen In Synthetic Mixture Using 1st Order Derivative Spectroscopy. International Journal of Pharmacy and Pharmaceutical Sciences. 2019 Oct; 11(10): 26-32en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205960
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber10en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2019v11i10.34797en_US
dc.subjectPamabromen_US
dc.subjectIbuprofenen_US
dc.subjectDerivative spectroscopyen_US
dc.subjectZero crossover pointen_US
dc.subjectAnalytical method validationen_US
dc.titleQuantitative Analysis Of Pamabrom And Ibuprofen In Synthetic Mixture Using 1st Order Derivative Spectroscopyen_US
dc.typeJournal Articleen_US
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