A study of high-sensitivity c-reactive protein in bronchial asthma.
dc.contributor.author | Sahoo, Ramesh Chandra | |
dc.contributor.author | Acharya, Preetam Rajgopal | |
dc.contributor.author | Noushad, T H | |
dc.contributor.author | Anand, R | |
dc.contributor.author | Acharya, Vishak K | |
dc.contributor.author | Sahu, Kausalya R | |
dc.date.accessioned | 2012-05-30T06:33:48Z | |
dc.date.available | 2012-05-30T06:33:48Z | |
dc.date.issued | 2009-10 | |
dc.description.abstract | Background. Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied. Objective. To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay. Methods. The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients. Results. There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects. Conclusions. The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients. | en_US |
dc.identifier.citation | Sahoo Ramesh Chandra, Acharya Preetam Rajgopal, Noushad T H, Anand R, Acharya Vishak K, Sahu Kausalya R. A study of high-sensitivity c-reactive protein in bronchial asthma. The Indian Journal of Chest Diseases and Allied Sciences, 2009 Oct; 51(4): 213-216. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/138749 | |
dc.language.iso | en | en_US |
dc.source.uri | https://medind.nic.in/iae/t09/i4/iaet09i4p213.pdf | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | High-sensitivity C-reactive protein | en_US |
dc.subject | Non-atopic asthma | en_US |
dc.subject | Acute phase proteins | en_US |
dc.subject.mesh | Adult | |
dc.subject.mesh | Asthma --blood | |
dc.subject.mesh | Asthma --physiopathology | |
dc.subject.mesh | Biological Markers --blood | |
dc.subject.mesh | C-Reactive Protein --metabolism | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Forced Expiratory Volume | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Nephelometry and Turbidimetry | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Severity of Illness Index | |
dc.subject.mesh | Spirometry | |
dc.title | A study of high-sensitivity c-reactive protein in bronchial asthma. | en_US |
dc.type | Article | en_US |
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