A study of high-sensitivity c-reactive protein in bronchial asthma.
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Date
2009-10
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Abstract
Background. Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied.
Objective. To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay.
Methods. The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured
using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients.
Results. There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects.
Conclusions. The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the
local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients.
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Keywords
C-reactive protein, High-sensitivity C-reactive protein, Non-atopic asthma, Acute phase proteins
Citation
Sahoo Ramesh Chandra, Acharya Preetam Rajgopal, Noushad T H, Anand R, Acharya Vishak K, Sahu Kausalya R. A study of high-sensitivity c-reactive protein in bronchial asthma. The Indian Journal of Chest Diseases and Allied Sciences, 2009 Oct; 51(4): 213-216.