Cyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats.

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dc.contributor.authorKaur, Fen_US
dc.contributor.authorSangha, G Ken_US
dc.contributor.authorBilaspuri, G Sen_US
dc.date.accessioned2009-05-28T12:41:24Z
dc.date.available2009-05-28T12:41:24Z
dc.date.issued1997-07-01en_US
dc.description.abstractEffect of cyclophosphamide administration (100 mg/kg body weight, ip, for 5 consecutive days) was studied on albino rat testis and epididymidis after 3 and 6 weeks of treatment. Cyclophosphamide decreased testis and cauda epididymidal weights, sperm count, motile and viable spermatozoa and increased percentage of abnormal spermatozoa. The biochemical changes observed in the testis include increase in acid and alkaline phosphatase activities and decrease in proteins and activity of lactate dehydrogenase. The levels of lipids and total cholesterol were not affected. In the epididymidis cyclophosphamide caused decrease in the tubular diameter and increase in its epithelial height. It is concluded that cyclophosphamide brings about structural and biochemical changes in the testis and epididymidis.en_US
dc.description.affiliationDepartment of Zoology, College of Basic Sciences & Humanities, Punjab Agricultural University, Ludhiana, India.en_US
dc.identifier.citationKaur F, Sangha GK, Bilaspuri GS. Cyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats. Indian Journal of Experimental Biology. 1997 Jul; 35(7): 771-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58422
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents, Alkylating --adverse effectsen_US
dc.subject.meshCyclophosphamide --adverse effectsen_US
dc.subject.meshEpididymis --drug effectsen_US
dc.subject.meshImmunosuppressive Agents --adverse effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshTestis --drug effectsen_US
dc.titleCyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats.en_US
dc.typeJournal Articleen_US
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