Global Longitudinal Strain Value and its Association with Coronary Artery Disease Severity

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dc.contributor.authorSonawane, Rohan Gen_US
dc.contributor.authorPonde, C. K.en_US
dc.date.accessioned2025-08-13T09:33:17Z
dc.date.available2025-08-13T09:33:17Z
dc.date.issued2025-03
dc.description.abstractBackground: Coronary Artery Disease (CAD) is one of the commonest non communicable cause of mortality and morbidity in the world today. Global Longitudinal Strain (GLS) Assessment can be an important tool inassessing severity of CAD. Aim: To assess role of GLS in predicting severity of CAD. Material and Methods: 160 patients, aged 18 to 75, suspected of CAD, underwent transthoracic echocardiograms before coronary angiography. Simpson’s method was used to measure LVEF. Depth-adjusted 2D images of the LV were taken in various views for offline measurement of 2D speckle-tracking myocardial strain. Global peak systolic strain was calculated by averaging six regional values from different views to measure longitudinal strain. Results: In this study, patients with significant CAD exhibited significantly lower GLS compared to those with non-significant CAD (-15.89 + 2.84% vs -18.36 +2.60%, p = 0.0001). As CAD severity increased, GLS values decreased significantly (-17.14 + 2.57% vs -16.27+2.42% vs -14.74+2.78%). A decremental trend in GLS with increasing CAD severity was observed, indicating a higher risk of multi- vessel disease with lower GLS values (p<0.0001). Conclusion: Reduced GLS indicates early LV systolic dysfunction in significant CAD patients. Thus, GLS measurement serves as an important diagnostic tool for predicting severe CAD.en_US
dc.identifier.affiliationsDepartment of Cardiology, P. D. Hinduja hospital and Medical Research Centre, Mahim, Mumbai, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, P. D. Hinduja hospital and Medical Research Centre, Mahim, Mumbai, Indiaen_US
dc.identifier.citationSonawane Rohan G, Ponde C. K. . Global Longitudinal Strain Value and its Association with Coronary Artery Disease Severity . JK Science Journal of Medical Education and Research. 2025 Mar; 27(1): 3-8en_US
dc.identifier.issn0972-1177
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252428
dc.languageenen_US
dc.publisherDr. Annil Mahajan from Jammu (J&K), Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume27en_US
dc.source.urihttps://journals.indexcopernicus.com/api/file/viewByFileId/2343071en_US
dc.subjectGlobal Longitudinal Strainen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectLV systolic dysfunctionen_US
dc.titleGlobal Longitudinal Strain Value and its Association with Coronary Artery Disease Severityen_US
dc.typeJournal Articleen_US
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