Pre-electroconvulsive shock administration of calcium channel blockers reduces retrograde amnesia induced by ECS.

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dc.contributor.authorSushma, Men_US
dc.contributor.authorSudha, Sen_US
dc.contributor.authorGuido, Sen_US
dc.date.accessioned2009-05-28T12:33:22Z
dc.date.available2009-05-28T12:33:22Z
dc.date.issued2004-11-14en_US
dc.description.abstractEffect of pre-electroconvulsive shock (ECS) administration of calcium channel blockers (CCBs) like verapamil, diltiazem, nifedipine, nimodipine, flunarizine and cinnarizine on retrograde amnesia induced by ECS was examined using passive avoidance paradigm in rats. The groups (Gr 1-7) of adult, male Wistar rats received true ECS with CCBs (5mg/kg; i.p) or vehicle (10 ml/kg; ip) and other groups (Gr 8-14) received sham ECS with CCBs (5mg/kg; i.p) or vehicle (10 ml/kg; i.p). The anti-amnestic activity of CCBs were evaluated using the passive avoidance paradigm in rats. Results showed that, the baseline latencies for all the groups did not differ significantly. Rats receiving true ECS produced significantly lower latencies. There was increase in the post ECS step through latencies of the rats administered CCBs before ECS. Therefore, pre-ECS administration of calcium channel blockers might reduce retrograde amnesia produced by ECS without altering seizure duration.en_US
dc.description.affiliationDepartment of Pharmacology, St John's Medical College, Bangalore 560 034, India.en_US
dc.identifier.citationSushma M, Sudha S, Guido S. Pre-electroconvulsive shock administration of calcium channel blockers reduces retrograde amnesia induced by ECS. Indian Journal of Experimental Biology. 2004 Nov; 42(11): 1141-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58242
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAmnesia --drug therapyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAvoidance Learning --physiologyen_US
dc.subject.meshCalcium Channel Blockers --administration & dosageen_US
dc.subject.meshElectroshocken_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSeizures --drug therapyen_US
dc.titlePre-electroconvulsive shock administration of calcium channel blockers reduces retrograde amnesia induced by ECS.en_US
dc.typeJournal Articleen_US
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