Synthesis and evaluation of sodium carboxymethyl cellulose azo polymer for colon specificity.

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dc.contributor.authorOjha, Mini
dc.contributor.authorMadhav, N V Satheesh
dc.contributor.authorSingh, Anita
dc.date.accessioned2015-12-11T07:37:45Z
dc.date.available2015-12-11T07:37:45Z
dc.date.issued2012
dc.description.abstractSodium carboxymethyl cellulose is an excellent pharmaceutical excipient. It possesses good filmability, mucoadhesiv-ity, viscolising capacity and bindability. The current aim of our research work is to synthesize a novel colon targeting polymer by using sodium carboxymethyl cellulose and glycine for colon targeting and to screen its colon specificity by in-vitro release model. Sodium carboxymethyl cellulose was subjected for synthesizing its derivative with glycine using azo linkage. The azo polymeric conjugate was evaluated for its color, solubility, Rf value, melting point, IR and 1HNMR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter. The research study revealed that the sodium carboxymethyl cellulose azo derivative showed promising colon specificity for a period of 120 minutes in a controlled manner along with modified solubility. So it can serve as a potential colon targeting polymer.en_US
dc.identifier.citationOjha Mini, Madhav N V Satheesh, Singh Anita. Synthesis and evaluation of sodium carboxymethyl cellulose azo polymer for colon specificity. International Current Pharmaceutical Journal. 2012; 1(8): 209-212.en_US
dc.identifier.issn2224-9486
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/167857
dc.language.isoenen_US
dc.source.urihttps://www.banglajol.info/index.php/ICPJ/article/view/11252en_US
dc.subjectColon targeted deliveryen_US
dc.subjectProdrugen_US
dc.subjectDextran conjugatesen_US
dc.subjectAzo conjugatesen_US
dc.subjectAzoreductaseen_US
dc.subjectmicrofloraen_US
dc.subjectactivated systemen_US
dc.titleSynthesis and evaluation of sodium carboxymethyl cellulose azo polymer for colon specificity.en_US
dc.typeArticleen_US
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