Phenotypic and Genetic Characterization of Antimicrobial Profiles of Helicobacter pylori Strains in Cuba.

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dc.contributor.authorLlanes, Rafael
dc.contributor.authorSoria, Claudia
dc.contributor.authorNagashima, Shigeo
dc.contributor.authorKobayashi, Nobumichi
dc.contributor.authorGala, Angela
dc.contributor.authorGuzmán, Daymi
dc.contributor.authorFeliciano, Onelkis
dc.contributor.authorValdés, Lidunka
dc.contributor.authorGutiérrez, Oderay
dc.contributor.authorFernández, Heriberto
dc.contributor.authorLlop, Alina
dc.contributor.authorWada, Akihiro
dc.date.accessioned2016-02-18T06:13:07Z
dc.date.available2016-02-18T06:13:07Z
dc.date.issued2010-04
dc.description.abstractThe study evaluated the antibiotic resistance patterns of Helicobacter pylori strains against metronidazole and clarithromycin in a hospital in Havana, Cuba. Eighty-five percent, 22.5%, and 10% of 40 H. pylori strains investigated were resistant to metronidazole, ciprofloxacin, and clarithromycin respectively but all were susceptible to amoxicillin and tetracycline. RdxA truncation was found only in metronidazole-resistant strains. In such strains, reported are eight and two novel mutations in the rdxA and frxA genes respectively. Two-point mutations in the 23S rRNA genes of clarithromycin-resistant strains were detected. A high prevalence of metronidazole resistance was found in Cuban H. pylori strains. Mutations in the rdxA gene may contribute more significantly than frxA gene to the high level of resistance to metronidazole. This study supports the need to continue monitoring the antibiotic susceptibility in H. pylori in Cuba to guide the treatment of such infection.en_US
dc.identifier.citationLlanes Rafael, Soria Claudia, Nagashima Shigeo, Kobayashi Nobumichi, Gala Angela, Guzmán Daymi, Feliciano Onelkis, Valdés Lidunka, Gutiérrez Oderay, Fernández Heriberto, Llop Alina, Wada Akihiro. Phenotypic and Genetic Characterization of Antimicrobial Profiles of Helicobacter pylori Strains in Cuba. Journal of Health, Population and Nutrition. 2010 Apr; 28(2): 124-129.en_US
dc.identifier.issn1606-0997
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/173370
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980873/?report=classicen_US
dc.subjectAntibiotic resistanceen_US
dc.subjectGene mutationsen_US
dc.subjectHelicobacter pylorien_US
dc.subjectCubaen_US
dc.titlePhenotypic and Genetic Characterization of Antimicrobial Profiles of Helicobacter pylori Strains in Cuba.en_US
dc.typeArticleen_US
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