Phenotypic and Genetic Characterization of Antimicrobial Profiles of Helicobacter pylori Strains in Cuba.
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Date
2010-04
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Abstract
The study evaluated the antibiotic resistance patterns of Helicobacter pylori strains against metronidazole and
clarithromycin in a hospital in Havana, Cuba. Eighty-five percent, 22.5%, and 10% of 40 H. pylori strains
investigated were resistant to metronidazole, ciprofloxacin, and clarithromycin respectively but all were
susceptible to amoxicillin and tetracycline. RdxA truncation was found only in metronidazole-resistant
strains. In such strains, reported are eight and two novel mutations in the rdxA and frxA genes respectively.
Two-point mutations in the 23S rRNA genes of clarithromycin-resistant strains were detected. A high prevalence
of metronidazole resistance was found in Cuban H. pylori strains. Mutations in the rdxA gene may
contribute more significantly than frxA gene to the high level of resistance to metronidazole. This study
supports the need to continue monitoring the antibiotic susceptibility in H. pylori in Cuba to guide the
treatment of such infection.
Description
Keywords
Antibiotic resistance, Gene mutations, Helicobacter pylori, Cuba
Citation
Llanes Rafael, Soria Claudia, Nagashima Shigeo, Kobayashi Nobumichi, Gala Angela, Guzmán Daymi, Feliciano Onelkis, Valdés Lidunka, Gutiérrez Oderay, Fernández Heriberto, Llop Alina, Wada Akihiro. Phenotypic and Genetic Characterization of Antimicrobial Profiles of Helicobacter pylori Strains in Cuba. Journal of Health, Population and Nutrition. 2010 Apr; 28(2): 124-129.