Evaluation of the Effects of Alpha-Tocopherol, Quercetin and their Combination on Ethanol-Induced Pancreatic and Duodenal Mucosal injuries: An Experimental Study

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dc.contributor.authorAkinrinde, A. S.en_US
dc.contributor.authorAjibade, T. O.en_US
dc.date.accessioned2024-09-24T06:22:50Z
dc.date.available2024-09-24T06:22:50Z
dc.date.issued2024-03
dc.description.abstractAim: In this study, the effects of alpha-tocopherol (AT), quercetin (QT) or their combination on ethanol-induced pancreatic and duodenal mucosal damage were investigated in rats using morphological and biochemical evaluations.Study Design: Experimental study.Place and Duration of Study: University of Ibadan, Ibadan, Nigeria.Methodology: Ethanol-induced injuries were produced by oral administration of 40% ethanol (0.2 ml/day) for 40 consecutive days, while a control group of rats was served distilled water. Other groups received AT (2.5 mg/kg), QT (50 mg/kg) or their combination with 40% ethanol during the experimental period.Results: Blood glucose level was significantly (p<0.05) increased in ethanol-treated rats relative to controls. Ethanol administration caused shrinkage of insulin-secreting islets tissues in the pancreas, while lesions such as erosions, loss of villi and severe inflammatory cell infiltrations of the mucosa and sub-mucosa were observed in the duodenum. These changes were accompanied by significant elevation in the levels of hydrogen peroxide (H2O2), malondialdehyde (MDA) and advanced oxidation protein products (AOPP) in the pancreas and duodenum, along with reduced activities of glutathione peroxidase (GPx) and glutathione S-transferase (GST). Treatment of rats with AT, QT, and especially their combination, yielded profound reversal of ethanol-induced effects indicated by restoration of blood glucose to control levels, preservation of pancreatic and duodenal morphology and the inhibition of ethanol-induced oxidative stress.Conclusion: Overall, dietary supplementation with AT and/or QT could potentially counteract the adverse effects associated with chronic alcohol consumption.en_US
dc.identifier.affiliationsDepartment of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.affiliationsDepartment of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.citationAkinrinde A. S., Ajibade T. O. . Evaluation of the Effects of Alpha-Tocopherol, Quercetin and their Combination on Ethanol-Induced Pancreatic and Duodenal Mucosal injuries: An Experimental Study . International Journal of Medical Research & Health Sciences. 2024-Mar; 33(3): 14-26en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226824
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber3en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/10.9734/ijbcrr/2024/v33i3860en_US
dc.subjectAlcoholen_US
dc.subjectantioxidantsen_US
dc.subjectpancreasen_US
dc.subjectduodenumen_US
dc.subjectoxidative stressen_US
dc.titleEvaluation of the Effects of Alpha-Tocopherol, Quercetin and their Combination on Ethanol-Induced Pancreatic and Duodenal Mucosal injuries: An Experimental Studyen_US
dc.typeJournal Articleen_US
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