Adjuvant activity of some nonpyrogenic hydrophobic analogues of muramyl dipeptide in enhancing the primary humoral and cell mediated immune responses in guinea pig model.

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dc.contributor.authorSaxena, R Pen_US
dc.contributor.authorPuri, Aen_US
dc.contributor.authorSaxena, K Cen_US
dc.contributor.authorShukla, Ren_US
dc.contributor.authorHaq, Wen_US
dc.contributor.authorRizvi, S Yen_US
dc.contributor.authorKundu, Ben_US
dc.contributor.authorMathur, K Ben_US
dc.date.accessioned2009-05-28T13:16:12Z
dc.date.available2009-05-28T13:16:12Z
dc.date.issued1991-02-01en_US
dc.description.abstractFive muramyl dipeptide analogues synthesized by derivatization of gamma-carboxyl of D-isoglutamine residue of MDP into alkyl amides or incorporation of lysine residue at the site via epsilon-NH2 function were evaluated for immuno-adjuvant activity. Derivatization of gamma-carboxyl of D-isoglutamine into butyl, octyl and dibutyl residues stimulated delayed type of hypersensitivity (DTH) response, the maximum stimulation being observed with octyl amide. Introduction of lauryl amide residue abolished DTH response. The antibody response was impaired with all the alkyl amide analogues except for the lysyl amide derivative with which the response was higher than MDP. Correlation was observed between DTH response and macrophage migration.en_US
dc.description.affiliationDivision of Biochemistry, Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.citationSaxena RP, Puri A, Saxena KC, Shukla R, Haq W, Rizvi SY, Kundu B, Mathur KB. Adjuvant activity of some nonpyrogenic hydrophobic analogues of muramyl dipeptide in enhancing the primary humoral and cell mediated immune responses in guinea pig model. Indian Journal of Experimental Biology. 1991 Feb; 29(2): 111-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59187
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetylmuramyl-Alanyl-Isoglutamine --analogs & derivativesen_US
dc.subject.meshAdjuvants, Immunologicen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Formationen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHypersensitivity, Delayeden_US
dc.subject.meshImmunity, Cellularen_US
dc.titleAdjuvant activity of some nonpyrogenic hydrophobic analogues of muramyl dipeptide in enhancing the primary humoral and cell mediated immune responses in guinea pig model.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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