The comparisons of the efficacy of two fixed dose combinations, i.e. Salmeterol and Fluticasone vs. Formoterol and Tiotropium bromide in moderate to severe COPD patients

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dc.contributor.authorB., Dharmarajen_US
dc.contributor.authorG., Prashanthen_US
dc.contributor.authorS., Basavarajen_US
dc.date.accessioned2020-04-23T07:50:37Z
dc.date.available2020-04-23T07:50:37Z
dc.date.issued2018-07
dc.description.abstractBackground: Bronchodilators are essential for symptomatic management of all stages of chronic obstructive pulmonary disease (COPD). For patients whose COPD is not sufficiently controlled by monotherapy, combining a ß2-agonist with either inhaled steroid or anticholinergic drug is a convenient way of delivering treatment. Currently, there is no documentation to say that one drug is superior to other or the contrary, but a combination of two drugs is more effective than giving single drug alone in patients suffering from COPD.Methods: The study was prospective, open labelled, randomized, comparative interventional clinical study conducted by the Departments of Pharmacology and Medicine, Basaveshwara Medical College and Hospital, Chitradurga in 60 moderates to severe COPD patients.Results: Both the treatments i.e. Salmeterol/Fluticasone and Tiotropium/Formoterol were equally effective as far as the improvement of the lung functions and Borg dyspnoea score are concerned. The difference in improvement with the combination of Salmeterol/Fluticasone was not statistically significant (p>0.05) compared to the combination of Tiotropium/Formoterol. However, Salmeterol/Fluticasone was found to be better than Tiotropium/Formoterol in improving the lung function of moderate to severe COPD patients.Conclusions: Salmeterol/Fluticasone is efficacious and better than Tiotropium /Formoterol combination for maintenance therapy in moderate to severe COPD patients.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.citationB. Dharmaraj, G. Prashanth, S. Basavaraj. The comparisons of the efficacy of two fixed dose combinations, i.e. Salmeterol and Fluticasone vs. Formoterol and Tiotropium bromide in moderate to severe COPD patients. International Journal of Basic & Clinical Pharmacology. 2018 Jul; 7(7): 1351-1356en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199757
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber7en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20182681en_US
dc.subjectCOPDen_US
dc.subjectFDCen_US
dc.subjectLABAen_US
dc.subjectICSen_US
dc.subjectInhaled bronchodilatorsen_US
dc.subjectTiotropiumen_US
dc.titleThe comparisons of the efficacy of two fixed dose combinations, i.e. Salmeterol and Fluticasone vs. Formoterol and Tiotropium bromide in moderate to severe COPD patientsen_US
dc.typeJournal Articleen_US
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