Cyclosporin and mitochondria: a neuroprotective approach .

Simple item page
dc.contributor.authorSingh, Alok
dc.contributor.authorKhare, Vivek
dc.date.accessioned2014-12-16T07:01:30Z
dc.date.available2014-12-16T07:01:30Z
dc.date.issued2013-05
dc.description.abstractCyclosporin A (CsA) an immunophilin, discovered in 1969 and approved in 1983 to be used as immunosuppressant agent and is widely used in organ transplantation and auto-immune disorders. Its ability to alter mitochondria and apoptotic pathways makes it attractive agent to be employed in variety of diseases including age related neurodegenerative diseases. Mitochondria play pivotal role in cell energetics and reactive oxygen species production and are known to be key regulator of apoptosis hence it is important in a wide range of diseases. The structural and functional properties of mitochondria enable the targeting of drugs supposed to modulate the function of organelle for therapeutic advantage. By targeting mitochondria we can prevent oxidative damage associated with neurodegenerative diseases and ischemia and reperfusion tissue injury. Similarly targeting Bcl-2 can be helpful in cancer by triggering apoptosis.en_US
dc.identifier.citationSingh Alok, Khare Vivek. Cyclosporin and mitochondria: a neuroprotective approach. International Journal of Basic & Clinical Pharmacology. 2013 May-Jun; 2(3): 339-340.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153888
dc.language.isoenen_US
dc.source.urihttps://www.ijbcp.com/?mno=34025en_US
dc.subjectCyclosporinen_US
dc.subjectMitochondriaen_US
dc.titleCyclosporin and mitochondria: a neuroprotective approach .en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijbcp2013v2n3p339.pdf
Size:
280.98 KB
Format:
Adobe Portable Document Format
Description:
Letter to the Editor
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
International Journal of Basic & Clinical Pharmacology