Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery

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dc.contributor.authorKondhalkar, A.en_US
dc.contributor.authorMore, K.en_US
dc.contributor.authorKumar, S.en_US
dc.date.accessioned2020-05-05T07:04:28Z
dc.date.available2020-05-05T07:04:28Z
dc.date.issued2019-11
dc.description.abstractIntroduction:Preterm birth (PTB) is a major determinant of neonatal mortality and morbidity. Preterm babies are prone to serious illness or death during the neonatal period.PTB is one of the unresolved problems in clinical obstetrics and one of the greatest threats to the developing fetus, there is need to determine predictive biomarker for preterm delivery. Therefore present study aimed to assess serum levels of ceruloplasmin and Alkaline phosphatase inpreterm and full-term delivery.Materials andMethods:The present study includes total 80 subjects that comprise forty women presenting with preterm onset of labor followed by delivery and forty women who delivered at term served as controls.Blood Samples from the subjects were obtained for ceruloplasmin and Alkaline phosphatase estimation, when patient was in labor.Serum ceruloplasmin and alkaline phosphatase measured spectrophotometrically. Serum ceruloplasmin was estimated by Herbert A Ravinand Henry et al.method. Serum alkaline phosphatase was estimated by Kinetic p-NPP method.Results:Serum ceruloplasmin levels were significantly increased (P<0.001) in preterm delivery as compared to full term delivery. Alkaline phosphatase levels are significantly increased in preterm delivery (p<0.001) as compared to full term delivery. Conclusion: Our study showed that elevated levels of ceruloplasmin and alkaline phosphatase may be associated with preterm delivery in asymptomaticpregnant women. The elevated ALP may be due to mild chronic subclinical infection which may be responsible for preterm delivery. Ceruloplasmin is acute phase reactant,increaseddue toanantioxidant defence mechanism against oxidative stress.en_US
dc.identifier.affiliationsDepartment of Biochemistry, MGM Medical College, Kamothe, Navi Mumbai, India.en_US
dc.identifier.affiliationsDepartment of Biochemistry, MGM Medical College, Kamothe, Navi Mumbai, India.en_US
dc.identifier.affiliationsDepartment of OBGY, MGM Medical College, Kamothe, Navi Mumbai, Indiaen_US
dc.identifier.citationKondhalkar A., More K., Kumar S.. Ceruloplasmin and Alkaline Phosphatase Levels in Preterm Delivery . International Journal of Biochemistry Research & Review. 2019 Nov; 28(2): 1-6en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200748
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume28en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2019/v28i230140en_US
dc.subjectPreterm Birth (PTB)en_US
dc.subjectceruloplasminen_US
dc.subjectalkaline phosphataseen_US
dc.subjectfull term deliveryen_US
dc.titleCeruloplasmin and Alkaline Phosphatase Levels in Preterm Deliveryen_US
dc.typeJournal Articleen_US
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