Design And Development Of Rilpivirine Nanoparticle Containing Chitosan Using Ionic Gelation Method For Hiv Infections

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dc.contributor.authorPatel, M.en_US
dc.contributor.authorPatel, N. V.en_US
dc.contributor.authorPatel, T. B.en_US
dc.date.accessioned2020-09-24T08:01:45Z
dc.date.available2020-09-24T08:01:45Z
dc.date.issued2020-02
dc.description.abstractObjective: The primary objective of the current research was to prepare rilpivirine loaded Nanoparticles containing Chitosan using the ionic gelation method for HIV infections. Methods: The nanoparticles of rilpivirine were prepared using the ionic gelation technique. Further, nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and in vitro drug release. Results: The optimized nanoparticles were found with a particle size of 130.30±5.29 nm (mean±SD) and entrapment efficiency (% EE) of 77.10±0.50%. Scanning electron microscopy technique exposed spherical particles with uniform size. It was observed that the nanoparticles created showed the absence of the crystalline nature of the drug and its switch to the amorphous state. Results showed that more than 45% of the pure drug is released in 50 min and after 90 min almost about 95% of the drug is released. Conclusion: The research study concluded that the in vitro release profile of nanoparticles was found to be sustained up to 24 hr. Sustained release of the rilpivirine could improve patient obedience to drug regimens, growing action effectiveness.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Science, Saurashtra University, Rajkot, Gujarat, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Science, Saurashtra University, Rajkot, Gujarat, Indiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, Indiaen_US
dc.identifier.citationPatel M., Patel N. V., Patel T. B.. Design And Development Of Rilpivirine Nanoparticle Containing Chitosan Using Ionic Gelation Method For Hiv Infections. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Feb; 12(2): 113-118en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206052
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i2.35814en_US
dc.subjectRilpivirineen_US
dc.subjectChitosanen_US
dc.subjectNanoparticlesen_US
dc.subjectHIVen_US
dc.titleDesign And Development Of Rilpivirine Nanoparticle Containing Chitosan Using Ionic Gelation Method For Hiv Infectionsen_US
dc.typeJournal Articleen_US
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