NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.

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dc.contributor.authorOsawa, Yasunorien_US
dc.contributor.authorOsawa, Kayo Kumaren_US
dc.contributor.authorMiyaishi, Aikoen_US
dc.contributor.authorHiguchi, Mihoen_US
dc.contributor.authorTsutou, Akimitsuen_US
dc.contributor.authorMatsumura, Sueoen_US
dc.contributor.authorTabuchi, Yoshikien_US
dc.contributor.authorTsubota, Noriakien_US
dc.contributor.authorTakahashi, Juroen_US
dc.date.accessioned2009-05-27T17:49:30Z
dc.date.available2009-05-27T17:49:30Z
dc.date.issued2007-01-05en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractWe investigated the associations between lung cancer and the gene polymorphisms of the drug metabolizing enzymes, containing cytochrome P450 1A1 (CYP1A1), cytochrome P450 1A2 (CYP1A2), glutathione S-transferase class mu (GSTM1), and N-acetyltransferase 2 (NAT2). The study involved 113 lung cancer patients and 121 non-cancer controls divided into never, light and heavy smokers according to pack-years of smoking in Japanese by using PCR-RFLP. For light smokers, the lung cancer risk of NAT2 intermediate-slow was significantly increased [the adjusted odds ratio (OR): 10.9, 95% confidence intervals (95%CI): 1.75-67.5, P-value: 0.010]. Moreover, never smokers having joint genotypes of NAT2 intermediate-slow and CYP1A2*1F A/A was also associated with increased the lung cancer risk (OR: 4.95, 95% CI: 1.19-20.6, P-value: 0.028). We suggested that light smokers with intermediate-slow NAT2 activity were at highest risk for lung cancer and the gene-gene interaction based on intermediate-slow NAT2 activity and high CYP1A2 activity would be increased a lung cancer risk among never smokers.en_US
dc.description.affiliationKobe University Graduate School of Medicine, Tomogaoka, Sumaku, Kobe 654-0142, Japan.en_US
dc.identifier.citationOsawa Y, Osawa KK, Miyaishi A, Higuchi M, Tsutou A, Matsumura S, Tabuchi Y, Tsubota N, Takahashi J. NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status. Asian Pacific Journal of Cancer Prevention. 2007 Jan-Mar; 8(1): 103-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37965
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdenocarcinoma --epidemiologyen_US
dc.subject.meshAgeden_US
dc.subject.meshArylamine N-Acetyltransferase --geneticsen_US
dc.subject.meshCarcinoma, Squamous Cell --epidemiologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCytochrome P-450 CYP1A2 --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlutathione Transferase --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshJapanen_US
dc.subject.meshLung Neoplasms --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Genetic --geneticsen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking --adverse effectsen_US
dc.subject.meshTime Factorsen_US
dc.titleNAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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