In vitro percutaneous absorption of verapamil.

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dc.contributor.authorJain, G Ken_US
dc.contributor.authorAgrawal, S Sen_US
dc.date.accessioned2009-05-28T15:10:40Z
dc.date.available2009-05-28T15:10:40Z
dc.date.issued1996-05-01en_US
dc.description.abstractThe in vitro percutaneous absorption of verapamil hydrochloride (VHCl) was investigated in order to assess its feasibility for transdermal development. The experiments were carried across mice and guinea pig skins using Keshary-Chien diffusion cell. The values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to mouse skin. Increased drug concentration in donor compartment increased value of J but decreased value of Kp. Under similar conditions, values of J and Kp were lowered for dorsal skin as compared to abdominal skin, both for mice and guinea pig. The results indicate that verapamil can be administered transdermally.en_US
dc.description.affiliationCollege of Pharmacy, Pushp Vihar Sec-III, New Delhi, India.en_US
dc.identifier.citationJain GK, Agrawal SS. In vitro percutaneous absorption of verapamil. Indian Journal of Experimental Biology. 1996 May; 34(5): 475-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61653
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdministration, Cutaneousen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channel Blockers --administration & dosageen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMiceen_US
dc.subject.meshSkin --metabolismen_US
dc.subject.meshVerapamil --administration & dosageen_US
dc.titleIn vitro percutaneous absorption of verapamil.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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